David S. Wishart

David Scott Wishart (born 1961) is a researcher in the fields of metabolomics, cheminformatics and bioinformatics.^[1][2] He is a professor in the Department of Biological Sciences at the University of Alberta, with cross appointments in the Faculty of Pharmacy and Pharmaceutical Sciences and the Department of Laboratory Medicine and Pathology. He also holds a joint appointment in metabolomics at the Pacific Northwest National Laboratory in Richland, Washington.^[3]

Biography[]

Wishart was born and raised in Edmonton, Alberta, and has two siblings, Ian and Alexandra (Sandy). His mother, Patricia worked as a naturalist and author; his father William was a wildlife biologist. Wishart received his BSc in physics from the University of Alberta in 1983 and his Master's (1986) and Ph.D. degrees (1991) in molecular biophysics and biochemistry from Yale University.^[4]

Research interests[]

Wishart has active research programs in precision health, cancer (lung, breast), infectious diseases (COVID-19), neurological diseases (Alzheimer's, ALS), kidney diseases, animal/livestock health, forestry research, microbiome research, food chemistry, structural biology, portable sensor systems and metabolomics technology development.

Publications[]

His papers have been cited more than 77,000 times. His most cited publications are:

Metabolomics[]

• Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration Nucleic acids research. 2006 Jan 1;34(suppl_1):D668-72. (open access) (Cited 3082 times, according to Google Scholar^[5])
• Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, Cheng D, Jewell K, Arndt D, Sawhney S, Fung C. HMDB: the human metabolome database Nucleic acids research. 2007 Jan 1;35(suppl_1):D521-6. (open access) (Cited 2702 times, according to Google Scholar.^[5])
• Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vázquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z. HMDB 4.0: the human metabolome database for 2018 Nucleic acids research. 2018 Jan 4;46(D1):D608-17. (Cited 2083 times, according to Google Scholar.^[5])
• Chong J, Soufan O, Li C, Caraus I, Li S, Bourque G, Wishart DS, Xia J. MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis Nucleic acids research. 2018 Jul 2;46(W1):W486-94. (Cited 2398 times, according to Google Scholar.^[5])
• Xia J, Sinelnikov IV, Han B, Wishart DS. MetaboAnalyst 3.0—making metabolomics more meaningful Nucleic acids research. 2015 Jul 1;43(W1):W251-7 (Cited 2465 times, according to Google Scholar.^[5])
• Xia J, Wishart DS. Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis. Current protocols in bioinformatics. 2016 Sep;55(1):14-0. (Cited1287 times, according to Google Scholar.^[5])
• Bouatra S, Aziat F, Mandal R, Guo AC, Wilson MR, Knox C, Bjorndahl TC, Krishnamurthy R, Saleem F, Liu P, Dame ZT. The human urine metabolome PloS one. 2013 Sep 4;8(9):e73076.(open access) (Cited 1079 times, according to Google Scholar.^[5])
• Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N. 5.0: a major update to the DrugBank database for 2018 Nucleic acids research. 2018 Jan 4;46(D1):D1074-82. (open access) (Cited 3083 times, according to Google Scholar.^[5])

Protein structure[]

• Wishart DS, Sykes BD, Richards FM. Relationship between nuclear magnetic resonance chemical shift and protein secondary structure Journal of molecular biology. 1991 Nov 20;222(2):311-33. (open access) (Cited 2157 times, according to Google Scholar.^[5])
• Wishart DS, Bigam CG, Yao J, Abildgaard F, Dyson HJ, Oldfield E, Markley JL, Sykes BD. 1 H, 13 C and 15 N chemical shift referencing in biomolecular NMR. Journal of biomolecular NMR. 1995 Sep 1;6(2):135-40. (Cited 2741 times, according to Google Scholar.^[5])
• Wishart DS, Sykes BD, Richards FM. The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy Biochemistry. 1992 Feb 1;31(6):1647-51. (open access) (Cited2572 times, according to Google Scholar.^[5])
• Wishart DS, Sykes BD. The 13 C chemical-shift index: a simple method for the identification of protein secondary structure using 13 C chemical-shift data Journal of biomolecular NMR. 1994 Mar;4(2):171-80. (Cited 2454 times, according to Google Scholar.^[5])

Microbiology[]

• Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR, Chaudhuri RR, Glasner JD, Horiuchi T, Keseler IM, Kosuge T, Mori H. Escherichia coli K-12: a cooperatively developed annotation snapshot—2005 Nucleic acids research. 2006 Jan 1;34(1):1-9. (open access) (Cited 622 times, according to Google Scholar.^[5])
• Arndt D, Grant JR, Marcu A, Sajed T, Pon A, Liang Y, Wishart DS. PHASTER: a better, faster version of the PHAST phage search tool Nucleic acids research. 2016 May 3;44(W1):W16-21. (open access) (Cited17829 times, according to Google Scholar.^[5])

Informatics[]

• Cruz JA, Wishart DS. Applications of machine learning in cancer prediction and prognosis Cancer informatics. 2006 Jan;2:117693510600200030.(Cited 999 times, according to Google Scholar.^[5]) (open access) (Cited 1061 times, according to Google Scholar.^[5])
• Baxevanis AD, Bader GD, Wishart DS, editors. Bioinformatics John Wiley & Sons; 2020 (open access) (Cited 1050 times, according to Google Scholar.^[5])

References[]