Developmental Origins of Health and Disease

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Developmental Origins of Health and Disease (abbreviated DOHaD) is an approach to medical research emphasizing the role of prenatal and perinatal exposure to environmental factors, such as undernutrition, in determining the development of human diseases in adulthood.[1][2] This approach includes an emphasis on epigenetic causes of adult chronic diseases, including the potential for such environmental causes to influence disease risk across generations.[1][3][4]

Origin[]

The DOHaD approach originated in studies by David Barker and his colleagues, which showed a strong relationship between infant mortality rates from 1921 to 1925 and ischemic heart disease rates from 1968 to 1978. This led to the fetal origins hypothesis of the origins of adult diseases, which proposed that this relationship was caused by differences in early life nutrition. This in turn led to greater interest in the roles of developmental plasticity and early life environmental exposures in adult disease. The World Congress on Fetal Origins of Adult Disease held two meetings – one in 2001 and the other in 2003 – summarizing then-new research in these areas. This congress later evolved into the International Society for Developmental Origins of Health and Disease.[1]

References[]

  1. ^ a b c Wadhwa, Pathik D.; Buss, Claudia; Entringer, Sonja; Swanson, James M. (September 2009). "Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms". Seminars in Reproductive Medicine. 27 (5): 358–368. doi:10.1055/s-0029-1237424. ISSN 1526-4564. PMC 2862635. PMID 19711246.
  2. ^ Gillman, Matthew W. (2005-10-27). "Developmental origins of health and disease". The New England Journal of Medicine. 353 (17): 1848–1850. doi:10.1056/NEJMe058187. ISSN 1533-4406. PMC 1488726. PMID 16251542.
  3. ^ Godfrey, Keith M; Lillycrop, Karen A; Burdge, Graham C; Gluckman, Peter D; Hanson, Mark A (May 2007). "Epigenetic Mechanisms and the Mismatch Concept of the Developmental Origins of Health and Disease". Pediatric Research. 61 (5 Part 2): 5R–10R. doi:10.1203/pdr.0b013e318045bedb. ISSN 0031-3998. PMID 17413851.
  4. ^ Heindel, Jerrold J.; Balbus, John; Birnbaum, Linda; Brune-Drisse, Marie Noel; Grandjean, Philippe; Gray, Kimberly; Landrigan, Philip J.; Sly, Peter D.; Suk, William (2015-10-01). "Developmental Origins of Health and Disease: Integrating Environmental Influences". Endocrinology. 156 (10): 3416–3421. doi:10.1210/en.2015-1394. ISSN 1945-7170. PMC 4588819. PMID 26241070.


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