Diacylglycerol O-acyltransferase 2

DGAT2
Identifiers
Aliases	DGAT2, ARAT, GS1999FULL, HMFN1045, diacylglycerol O-acyltransferase 2
External IDs	OMIM: 606983 MGI: 1915050 HomoloGene: 23580 GeneCards: DGAT2
EC number	2.3.1.76
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,801,535 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,182,719 bp
Gene ontology
Molecular function	• protein homodimerization activity; • acyltransferase activity, transferring groups other than amino-acyl groups; • acyltransferase activity; • 2-acylglycerol O-acyltransferase activity; • retinol O-fatty-acyltransferase activity; • transferase activity; • diacylglycerol O-acyltransferase activity;
Cellular component	• integral component of membrane; • intracellular membrane-bounded organelle; • lipid droplet; • perinuclear region of cytoplasm; • integral component of endoplasmic reticulum membrane; • membrane; • endoplasmic reticulum; • endoplasmic reticulum membrane; • mitochondrion;
Biological process	• regulation of cholesterol metabolic process; • lipid storage; • long-chain fatty-acyl-CoA metabolic process; • positive regulation of gluconeogenesis; • fat pad development; • cellular response to oleic acid; • fatty acid homeostasis; • positive regulation of triglyceride biosynthetic process; • lipid metabolism; • regulation of plasma lipoprotein particle levels; • negative regulation of fatty acid oxidation; • acylglycerol acyl-chain remodeling; • retinol metabolic process; • low-density lipoprotein particle clearance; • glycerol metabolic process; • diacylglycerol metabolic process; • cellular triglyceride homeostasis; • cholesterol homeostasis; • regulation of lipoprotein metabolic process; • triglyceride biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	84649
	67800
	ENSG00000062282
	ENSMUSG00000030747
	Q96PD7
	Q9DCV3
	NM_001253891; NM_032564
	NM_026384
	NP_001240820; NP_115953
	NP_080660
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein that in humans is encoded by the DGAT2 gene. ^[5]

Function[]

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs.

The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000062282 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030747 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Diacylglycerol O-acyltransferase 2". Retrieved 2017-07-18.

Further reading[]

Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2003). "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice". Biochem. Biophys. Res. Commun. 310 (2): 296–302. doi:10.1016/j.bbrc.2003.09.015. PMID 14521909.
Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML (2004). "Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells". J. Lipid Res. 45 (10): 1835–45. doi:10.1194/jlr.M300403-JLR200. PMID 15258194.
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007). "Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13". BMC Genet. 8: 17. doi:10.1186/1471-2156-8-17. PMC 1871603. PMID 17477860.
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007). "Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13". BMC Genet. 8: 17. doi:10.1186/1471-2156-8-17. PMC 1871603. PMID 17477860.
Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ (2007). "Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis". J. Biol. Chem. 282 (29): 21005–14. doi:10.1074/jbc.M702871200. PMC 2254492. PMID 17504763.
Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV (2007). "Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle". Am. J. Physiol. Endocrinol. Metab. 293 (6): E1772–81. doi:10.1152/ajpendo.00158.2007. PMID 17940217.
Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008). "Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis". J. Lipid Res. 49 (11): 2283–301. doi:10.1194/jlr.R800018-JLR200. PMC 3837458. PMID 18757836.
Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N (2009). "The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans". Clin. Sci. 116 (6): 531–7. doi:10.1042/CS20080306. PMID 18980578.
Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV (2009). "The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria". J. Biol. Chem. 284 (8): 5352–61. doi:10.1074/jbc.M805768200. PMC 2643492. PMID 19049983.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000062282 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030747 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Diacylglycerol O-acyltransferase 2". Retrieved 2017-07-18.

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