E. coli nitroreductase

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E. coli nitroreductase is a flavoprotein found in the bacteria Escherichia coli. It catalyses the reduction of nitro groups in a wide range of substrates to produce the corresponding hydroxylamine. Although its role in vivo is unclear, it has been identified as useful in the metabolism of a number of prodrugs in anti-cancer gene therapy.[1]

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References[]

  1. ^ Denny, W.A. "Nitroreductase-based GDEPT" Current Pharmaceutical Design, 2002, 8(15), 1349-1361.


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