EIF2C1

AGO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Identifiers
Aliases	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDs	OMIM: 606228 MGI: 2446630 HomoloGene: 81826 GeneCards: AGO1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,869,808 bp[1] End 35,930,532 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,328,805 bp[2] End 126,362,376 bp[2]
RNA expression pattern Bgee Top expressed in prostate tendon visceral pleura parietal pleura prosencephalon internal globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding miRNA binding endoribonuclease activity GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001948 protein binding single-stranded RNA binding RNA binding nucleic acid binding double-stranded RNA binding Cellular component cytoplasm polysome cytosol RISC complex P-body nucleoplasm RISC-loading complex nucleus ribonucleoprotein complex Biological process mRNA destabilization-mediated gene silencing by siRNA miRNA loading onto RISC involved in gene silencing by miRNA regulation of transcription, DNA-templated transcription, DNA-templated pre-miRNA processing nuclear-transcribed mRNA catabolic process positive regulation of gene expression post-transcriptional gene silencing by RNA miRNA-mediated gene silencing by inhibition of translation RNA secondary structure unwinding mRNA destabilization-mediated gene silencing by miRNA miRNA metabolic process regulation of translation positive regulation of transcription by RNA polymerase II production of miRNAs involved in gene silencing by miRNA positive regulation of NIK/NF-kappaB signaling Wnt signaling pathway, calcium modulating pathway gene silencing regulation of gene silencing by miRNA regulation of megakaryocyte differentiation negative regulation of gene expression negative regulation of angiogenesis RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26523	236511
Ensembl	ENSG00000092847	ENSMUSG00000041530
UniProt	Q9UL18	Q8CJG1
RefSeq (mRNA)	NM_012199 NM_001317122 NM_001317123	NM_153403 NM_001317173 NM_001317174 NM_001378879
RefSeq (protein)	NP_001304051 NP_001304052 NP_036331	NP_001304102 NP_001304103 NP_700452 NP_001365808
Location (UCSC)	Chr 1: 35.87 – 35.93 Mb	Chr 4: 126.33 – 126.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.^[5][6][7]

Function[]

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.^[7]

Model organisms[]

Model organisms have been used in the study of EIF2C1 function. A conditional knockout mouse line, called Eif2c1^{tm1a(KOMP)Wtsi[12][13]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[14][15][16]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[10][17] Twenty two tests were carried out on mutant mice and two significant abnormalities were observed: homozygous mutants were subviable and females also had decreased circulating aspartate transaminase levels. ^[10]

References[]

Further reading[]