EME1

EME1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
Identifiers
Aliases	EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
External IDs	OMIM: 610885 MGI: 3576783 HomoloGene: 16123 GeneCards: EME1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	50,381,483 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	94,544,790 bp
RNA expression pattern
	Top expressed in
	tendon; ; corpus epididymis; ; ovary; ; liver; ; testicle; ; vagina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; endonuclease activity; nuclease activity; GO:0001948 protein binding; hydrolase activity; metal ion binding; endodeoxyribonuclease activity; crossover junction endodeoxyribonuclease activity;
Cellular component	nucleolus; nucleoplasm; nucleus; Holliday junction resolvase complex;
Biological process	cellular response to DNA damage stimulus; DNA recombination; interstrand cross-link repair; nucleic acid phosphodiester bond hydrolysis; response to intra-S DNA damage checkpoint signaling; DNA repair; resolution of meiotic recombination intermediates; double-strand break repair; replication fork processing; mitotic intra-S DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	146956
	268465
	ENSG00000154920
	ENSMUSG00000039055
	Q96AY2
	Q8BJW7
	NM_001166131; NM_152463
	NM_177752; NM_001379688
	NP_001159603; NP_689676
	NP_808420; NP_001366617
	Wikidata
View/Edit Human	View/Edit Mouse

Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene.^[5]^[6] It forms a complex with MUS81 which resolves Holliday junctions.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154920 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039055 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ciccia A, Constantinou A, West SC (Jun 2003). "Identification and characterization of the human mus81-eme1 endonuclease". J Biol Chem. 278 (27): 25172–8. doi:10.1074/jbc.M302882200. PMID 12721304.
^ "Entrez Gene: EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe)".

Further reading[]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Oğrünç M, Sancar A (2003). "Identification and characterization of human MUS81-MMS4 structure-specific endonuclease". J. Biol. Chem. 278 (24): 21715–20. doi:10.1074/jbc.M302484200. PMID 12686547.
Abraham J, Lemmers B, Hande MP, et al. (2004). "Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells". EMBO J. 22 (22): 6137–47. doi:10.1093/emboj/cdg580. PMC 275438. PMID 14609959.
Blais V, Gao H, Elwell CA, et al. (2004). "RNA Interference Inhibition of Mus81 Reduces Mitotic Recombination in Human Cells". Mol. Biol. Cell. 15 (2): 552–62. doi:10.1091/mbc.E03-08-0580. PMC 329235. PMID 14617801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hiyama T, Katsura M, Yoshihara T, et al. (2006). "Haploinsufficiency of the Mus81–Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells". Nucleic Acids Res. 34 (3): 880–92. doi:10.1093/nar/gkj495. PMC 1360746. PMID 16456034.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154920 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039055 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12721304-5] Ciccia A, Constantinou A, West SC (Jun 2003). "Identification and characterization of the human mus81-eme1 endonuclease". J Biol Chem. 278 (27): 25172–8. doi:10.1074/jbc.M302882200. PMID 12721304.

[entrez-6] "Entrez Gene: EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe)".

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