ENTPD3

ENTPD3
Identifiers
Aliases	ENTPD3, CD39L3, HB6, NTPDase-3, ectonucleoside triphosphate diphosphohydrolase 3
External IDs	OMIM: 603161 MGI: 1321386 HomoloGene: 68171 GeneCards: ENTPD3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	40,428,744 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	120,397,393 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; islet of Langerhans; ; putamen; ; tibia; ; middle temporal gyrus; ; minor salivary gland; ; parotid gland; ; endometrium; ; periodontal fiber; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GO:0001948 protein binding; hydrolase activity; ATP binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity; 8-oxo-dGTP phosphohydrolase activity; dATP phosphohydrolase activity; dCTP phosphohydrolase activity; dUTP phosphohydrolase activity; dTTP phosphohydrolase activity; GTP phosphohydrolase activity; dGTP phosphohydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	nucleoside triphosphate catabolic process; nucleoside diphosphate catabolic process; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	956
	215446
	ENSG00000168032
	ENSMUSG00000041608
	O75355
	Q8BFW6
	NM_001248; NM_001291960; NM_001291961
	NM_178676
	NP_001239; NP_001278889; NP_001278890
	NP_848791
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.^[5]^[6]

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.
^ ^a ^b "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".

Further reading[]

Munkonda MN, Kauffenstein G, Kukulski F, et al. (2007). "Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists". Biochem. Pharmacol. 74 (10): 1524–34. doi:10.1016/j.bcp.2007.07.033. PMID 17727821.
Ivanenkov VV, Meller J, Kirley TL (2005). "Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling". Biochemistry. 44 (25): 8998–9012. doi:10.1021/bi047487z. PMID 15966724.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yang F, Hicks-Berger CA, Smith TM, Kirley TL (2001). "Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions". Biochemistry. 40 (13): 3943–50. doi:10.1021/bi002711f. PMID 11300774.
Smith TM, Lewis Carl SA, Kirley TL (1999). "Mutagenesis of two conserved tryptophan residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase". Biochemistry. 38 (18): 5849–57. doi:10.1021/bi990171k. PMID 10231536.
Smith TM, Kirley TL (1998). "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1". Biochim. Biophys. Acta. 1386 (1): 65–78. doi:10.1016/s0167-4838(98)00063-6. PMID 9675246.
Chadwick BP, Frischauf AM (1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mamm. Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168032 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041608 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9676430-5] Chadwick BP, Frischauf AM (Oct 1998). "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster". Genomics. 50 (3): 357–67. doi:10.1006/geno.1998.5317. PMID 9676430.

[entrez-6] "Entrez Gene: ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3".

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