ERH (gene)
ERH | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | ERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor | ||||||||||||||||||||||||
External IDs | OMIM: 601191 MGI: 108089 HomoloGene: 3274 GeneCards: ERH | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
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Location (UCSC) | Chr 14: 69.38 – 69.4 Mb | Chr 12: 80.68 – 80.69 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
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Enhancer of rudimentary | |||||||||
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![]() crystal structure of enhancer of rudimentary homologue (erh) | |||||||||
Identifiers | |||||||||
Symbol | ER | ||||||||
Pfam | PF01133 | ||||||||
InterPro | IPR000781 | ||||||||
PROSITE | PDOC00732 | ||||||||
SCOP2 | 1j24 / SCOPe / SUPFAM | ||||||||
TCDB | 3.A.16 | ||||||||
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In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[5][6][7]
The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[8]
From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[6] It has been proposed that this protein plays a role in the cell cycle.
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100632 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021131 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics. 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID 8786099.
- ^ a b Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495.
- ^ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
- ^ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics. 138 (4): 1163–1170. doi:10.1093/genetics/138.4.1163. PMC 1206255. PMID 7896098.
Further reading[]
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829. S2CID 33475235.
- Wan C, Tempel W, Liu ZJ, et al. (2005). "Structure of the conserved transcriptional repressor enhancer of rudimentary homolog". Biochemistry. 44 (13): 5017–23. doi:10.1021/bi047785w. PMID 15794639.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Jin T, Guo F, Serebriiskii IG, et al. (2007). "A 1.55 A resolution X-ray crystal structure of HEF2/ERH and insights into its transcriptional and cell-cycle interaction networks". Proteins. 68 (2): 427–37. doi:10.1002/prot.21343. PMID 17444515. S2CID 2003248.
External links[]
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)
Categories:
- Genes on human chromosome 14
- Protein families
- Human chromosome 14 gene stubs