From Wikipedia, the free encyclopedia
Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene .[5] [6] [7] [8]
Model organisms [ ] Model organisms have been used in the study of ERLIN2 function. A conditional knockout mouse line called Erlin2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute .[9] phenotypic screen [10] [11] [12] [13] [14] [15]
Erlin2 knockout mouse phenotype
Characteristic
Phenotype
All data available at.[10] [15]
Peripheral blood leukocytes 6 Weeks
Normal
Insulin
Normal
Haematology Normal
Homozygous viability at P14
Normal
Homozygous Fertility
Normal
Body weight
Normal
Neurological assessment
Normal
Grip strength
Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Eye morphology
Normal
Clinical chemistry Abnormal
Haematology Normal
Peripheral blood leukocytes 16 Weeks
Normal
Heart weight
Normal
Salmonella Normal
Cytotoxic T Cell Function
Normal
Spleen Immunophenotyping
Normal
Mesenteric Lymph Node Immunophenotyping
Normal
Bone Marrow Immunophenotyping
Normal
Epidermal Immune Composition
Normal
Influenza Challenge
Normal
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000147475 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031483 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y (Oct 1999). "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Cytogenetics and Cell Genetics . 85 (3–4): 227–31. doi :10.1159/000015298 . PMID 10449903 . S2CID 39559998 . ^ Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C (Aug 2005). "A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes" . Oncogene . 24 (33): 5235–45. doi :10.1038/sj.onc.1208741 PMID 15897872 . ^ Browman DT, Resek ME, Zajchowski LD, Robbins SM (Aug 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER" . Journal of Cell Science . 119 (Pt 15): 3149–60. doi :10.1242/jcs.03060 PMID 16835267 . ^ "Entrez Gene: ERLIN2 ER lipid raft associated 2" .^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ a b "International Mouse Phenotyping Consortium" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes" . Cell . 154 (2): 452–64. doi :10.1016/j.cell.2013.06.022 . PMC 3717207 PMID 23870131 . ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium" .
Further reading [ ]
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Reports . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Research . 14 (9): 1711–8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Pearce MM, Wang Y, Kelley GG, Wojcikiewicz RJ (Jul 2007). "SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells" . The Journal of Biological Chemistry . 282 (28): 20104–15. doi :10.1074/jbc.M701862200 PMID 17502376 .
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