Eric Poeschla

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Eric Murnane Poeschla is an American infectious disease physician, virologist and immunologist. After graduating from the Yale School of Medicine he completed his residency in internal medicine at the University of California, San Francisco School of Medicine in 1988, followed by a year of tropical medicine training and practice in the highlands of Papua New Guinea.[1] He was the project physician for the 1990 Vanderbilt University Petexbatun Region Maya Archaeology Expedition in Dos Pilas, Guatemala.[2] He did an infectious disease fellowship and post-doctoral training in virology at the University of California, San Diego School of Medicine, and was then recruited to Mayo Clinic College of Medicine in 1999, where he was Professor of Molecular Medicine and directed virology research focused on the HIV life cycle. He is interested in how viruses interact with, use, or evade cellular proteins as they replicate, as well as innate immunity, and viral emergence. Early work determined how FIV, the feline HIV-like virus, can or cannot execute its life cycle steps in cells of different species; the work also established the first FIV-based lentiviral vector system.[3][4] Subsequent research included contributions to identifying the role of a cellular protein (LEDGF) in the chromosomal attachment and integration step of HIV, and investigations of other cellular factors that regulate the HIV life cycle.[5][6][7][8][9] More recent studies have further concerned cellular innate immune defenses to other RNA viruses. The laboratory uses picornavirus RNA polymerase-transgenic mouse models to investigate Interferon-stimulated gene (ISG) responses triggered by viral double-stranded RNA via the sensor MDA5.[10][11][12] The mice have lifelong elevations of many ISGs and resist normally lethal challenges by numerous RNA and DNA viruses. However, they lack expected auto-inflammatory tradeoffs of chronic MDA5 activation and this unusual avoidance of autoimmunity or 'interferonopathy' is a main question of interest. In 2020, his laboratory and colleagues in Singapore described a restriction, or block, to primate lentiviruses (HIV and related simian viruses) in cells of large (Pteropid) bats.[13] Since 2014, Poeschla has been Professor of Medicine and Chief of the Infectious Diseases Division at the University of Colorado School of Medicine, where he also holds the Tim Gill Endowed Chair in HIV Research and has helped direct the institutional response to the COVID-19 pandemic.[14][15][16] Poeschla was elected to the Association of American Physicians (AAP) in 2016. He lives in Denver.

References[]

  1. ^ "Kundiawa General Hospital". PNG Health Watch. Retrieved 2021-10-29.
  2. ^ Lost City of the Maya Documentary, retrieved 2021-10-29
  3. ^ Poeschla, E. M.; Wong-Staal, F.; Looney, D. J. (1998). "Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors". Nature Medicine. 4 (3): 354–357. doi:10.1038/nm0398-354. ISSN 1078-8956. PMID 9500613. S2CID 6624732 – via Pubmed.
  4. ^ Poeschla, E. M.; Looney, D. J. (1998). "CXCR4 is required by a nonprimate lentivirus: heterologous expression of feline immunodeficiency virus in human, rodent, and feline cells". Journal of Virology. 72 (8): 6858–6866. doi:10.1128/JVI.72.8.6858-6866.1998. ISSN 0022-538X. PMC 109895. PMID 9658135.
  5. ^ Llano, Manuel; Saenz, Dyana T.; Meehan, Anne; Wongthida, Phonphimon; Peretz, Mary; Walker, William H.; Teo, Wulin; Poeschla, Eric M. (2006-10-20). "An essential role for LEDGF/p75 in HIV integration". Science. 314 (5798): 461–464. Bibcode:2006Sci...314..461L. doi:10.1126/science.1132319. ISSN 1095-9203. PMID 16959972. S2CID 24756699.
  6. ^ Kumar, Swati; Morrison, James H.; Dingli, David; Poeschla, Eric (2018-08-15). "HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products". Journal of Virology. 92 (16): e00001–18. doi:10.1128/JVI.00001-18. ISSN 1098-5514. PMC 6069178. PMID 29769349.
  7. ^ Fadel, Hind J.; Morrison, James H.; Saenz, Dyana T.; Fuchs, James R.; Kvaratskhelia, Mamuka; Ekker, Stephen C.; Poeschla, Eric M. (2014-09-01). "TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism". Journal of Virology. 88 (17): 9704–9717. doi:10.1128/JVI.01397-14. ISSN 1098-5514. PMC 4136317. PMID 24942577.
  8. ^ Meehan, Anne M.; Saenz, Dyana T.; Guevera, Rebekah; Morrison, James H.; Peretz, Mary; Fadel, Hind J.; Hamada, Masakazu; van Deursen, Jan; Poeschla, Eric M. (2014). "A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection". PLOS Pathogens. 10 (2): e1003969. doi:10.1371/journal.ppat.1003969. ISSN 1553-7374. PMC 3930637. PMID 24586169.
  9. ^ Morrison, James H.; Guevara, Rebekah B.; Marcano, Adriana C.; Saenz, Dyana T.; Fadel, Hind J.; Rogstad, Daniel K.; Poeschla, Eric M. (2014). "Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation". Journal of Virology. 88 (6): 3255–3272. doi:10.1128/JVI.03814-13. ISSN 1098-5514. PMC 3957917. PMID 24390322.
  10. ^ Miller, Caitlin M.; Barrett, Bradley S.; Chen, Jianfang; Morrison, James H.; Radomile, Caleb; Santiago, Mario L.; Poeschla, Eric M. (2020-04-16). "Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease". Journal of Virology. 94 (9): e00071–20. doi:10.1128/JVI.00071-20. ISSN 1098-5514. PMC 7163129. PMID 32051266.
  11. ^ Bankers, Laura; Miller, Caitlin; Liu, Guoqi; Thongkittidilok, Chommanart; Morrison, James; Poeschla, Eric M. (2020-05-15). "Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation". Journal of Immunology. 204 (10): 2791–2807. doi:10.4049/jimmunol.1901421. ISSN 1550-6606. PMC 7326337. PMID 32277054.
  12. ^ Painter, Meghan M.; Morrison, James H.; Zoecklein, Laurie J.; Rinkoski, Tommy A.; Watzlawik, Jens O.; Papke, Louisa M.; Warrington, Arthur E.; Bieber, Allan J.; Matchett, William E.; Poeschla, Eric M.; Rodriguez, Moses (2015). "Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity". PLOS Pathogens. 11 (12): e1005311. doi:10.1371/journal.ppat.1005311. ISSN 1553-7374. PMC 4669089. PMID 26633895.
  13. ^ Morrison, James H.; Miller, Caitlin; Bankers, Laura; Crameri, Gary; Wang, Lin-Fa; Poeschla, Eric M. (2020-09-15). "A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat". mBio. 11 (5): e01854–20. doi:10.1128/mBio.01854-20. ISSN 2150-7511. PMC 7492736. PMID 32934084.
  14. ^ "Poeschla named head of Division of Infectious Diseases". University of Colorado. August 21, 2014. Retrieved November 25, 2018.
  15. ^ "Eric Poeschla, M.D". University of Colorado Denver. 2014. Retrieved November 25, 2018.
  16. ^ "Eric M Poeschla's research". Retrieved November 25, 2018.


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