Ethyl lauroyl arginate

Ethyl lauroyl arginate
Names
	IUPAC name Ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate
	Other names Ethyl N(alpha)-lauroyl-L-arginate; Lauric arginate ethyl ester
Identifiers
CAS Number	48076-74-0;
3D model (JSmol)	Interactive image;
ChemSpider	163603;
E number	E243 (preservatives)
PubChem CID	188214;
UNII	E0K8J7A41B;
CompTox Dashboard (EPA)	DTXSID60893076 ;
	InChI InChI=1S/C20H40N4O3/c1-3-5-6-7-8-9-10-11-12-15-18(25)24-17(19(26)27-4-2)14-13-16-23-20(21)22/h17H,3-16H2,1-2H3,(H,24,25)(H4,21,22,23)/t17-/m0/s1 Key: XJTMYVOVQZMMKX-KRWDZBQOSA-N;
	SMILES CCCCCCCCCCCC(=O)NC(CCCN=C(N)N)C(=O)OCC;
Properties
Chemical formula	C20H40N4O3
Molar mass	384.565 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Ethyl lauroyl arginate (LAE) is a food preservative more commonly known as E243.^[1]^[2]

It has chemical formula C₂₀H₄₀N₄O₃ and is a drug for dermatological disorders.^[2]

Periodontal diseases[]

LAE has potential in treating gingivitis, and the more advanced periodontitis. In a study comparing ethyl lauroyl arginate in 0.147% mouthwash to chlorhexidine (CHX) 0.12% as an adjunctive therapy in the non-surgical treatment of periodontitis, the results showed there were no treatment-related adverse events. Total bacterial count and the specific pathogens were reduced at 4 weeks and 3 months by both mouthwashes with no statistical differences between them at neither periods of time. It was concluded that 0.147% LAE-containing mouthwash could be an alternative to the use of 0.12% CHX in the non-surgical therapy of periodontitis considering the similar clinical effects, more stable microbiological improvement and absence of adverse effects.^[3]

It is sold as the main active ingredient in Listerine Advanced Defence Gum Treatment^[4] and as one of the active ingredients in GUM Activital Mouthwash.^[5]

References[]

^ "EU Approved additives and E Numbers". Food Standards Agency. Retrieved 3 December 2018.
^ ^a ^b "Compound Summary for CID 188214 - Ethyl Lauroyl Arginate". PubChem. NIH.
^ Pilloni, Andrea; Orrù, Germano; Carere, Mauro; Scano, Alessandra (October 2017). "Adjunctive use of an Ethyl Lauroyl Arginate (LAE)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial". Minerva Stomatologica. 67 (1): 1–11. PMID 29087093.
^ "Product profile". Listerine Advanced Defence Gum Treatment.
^ "Product profile". Sunstar GUM.

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[1] "EU Approved additives and E Numbers". Food Standards Agency. Retrieved 3 December 2018.

[elapc-2] "Compound Summary for CID 188214 - Ethyl Lauroyl Arginate". PubChem. NIH.

[3] Pilloni, Andrea; Orrù, Germano; Carere, Mauro; Scano, Alessandra (October 2017). "Adjunctive use of an Ethyl Lauroyl Arginate (LAE)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial". Minerva Stomatologica. 67 (1): 1–11. PMID 29087093.

[4] "Product profile". Listerine Advanced Defence Gum Treatment.

[5] "Product profile". Sunstar GUM.

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