Eve Marder

Eve Marder
Born	New York City
Alma mater	Brandeis University, University of California, San Diego
Known for	Dynamic clamp method, studies on the stomatogastric nervous system
Awards	Member of the US National Academy of Sciences, Kavli Prize in Neuroscience
Scientific career
Fields	Neuroscience
Institutions	Brandeis University

Eve Marder is a University Professor and the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. At Brandeis, Marder is also a member of the Volen National Center for Complex Systems. Dr. Marder is known for her pioneering work on small neuronal networks which her team has interrogated via a combination of complementary experimental and theoretical techniques.

Marder is particularly well known in the community for her work on neural circuits in the crustacean stomatogastric nervous system (STNS), a small network of 30 neurons. She discovered that circuits are not “hard-wired” to produce a single output or behavior, but can be reconfigured by neuromodulators to produce many outputs and behaviors while still maintaining the integrity of the circuit. Her work has revolutionized the way scientists approach the studies of neural circuits with respect to the study of structural and functional behavior. The general principles that have resulted from her work are thought to be generally applicable to other neural networks, including those in humans.

Marder has received numerous awards for her pioneering work in the field including memberships in the National Academy of Sciences and the American Academy of Arts and Sciences. In 2013, she was named to the National Institute of Health working group for the BRAIN Initiative.

Career, research, and service[]

Marder was born in Manhattan and raised on the east coast. Although she loved biology from an early age, Marder has shared that she held very diverse academic interests prior to starting her undergraduate degree and in fact entered Brandeis University as an undergraduate in 1965 with a plan to study politics and become a lawyer.^[1] She would instead find herself re-captivated by the world of biology and switched majors to Biology after her freshman year. Marder has shared that a pivotal turning point in her scientific self-development was writing a paper on schizophrenia during an abnormal psychology class during her junior year. Her subsequent library studies on inhibition in neural signaling solidified her career goals to become a neuroscientist and launched her on what would become her lifelong academic path.^[1]

Marder received her B.A. from Brandeis University in 1969^[1] and subsequently completed Ph.D. studies at University of California, San Diego. It was during her time as a graduate student at UCSD that Marder would be introduced to the specific neural network, the lobster stomatogastric-ganglion system, that would prove pivotal for the rest of her academic career.^[1] Marder's doctoral work on the role of acetylcholine in the lobster STG led to a single-author paper in Nature.^[2] She completed her postdoctoral training at the University of Oregon in Eugene and the École Normale Supérieure in Paris, France. Marder subsequently began her independent research career at Brandeis University in 1978 as a faculty member in the department in Biology.

Her work on the 30 neurons that compose the lobster stomatogastric ganglion (STG) produced many notable findings. She found that circuits can be modulated by many neuromodulators, which act on the level of populations of neurons, unlike some neurotransmitters, which can only affect specific target neurons. She pioneered work on plasticity and homeostasis, revealing more about how the brain can change dramatically during learning and development yet remain structurally stable. Her recent work examining network variability among healthy individuals shows that a variety of network parameters can produce the same behavioral outcome, challenging a long-standing goal in theoretical neuroscience to model 'ideal' neurons and neural circuits.^[3]

Along with Larry Abbott, she also developed the dynamic clamp method, which enables an experimenter to induce mathematically modeled conductances into living neurons to view the output of theoretical circuits.^[4]

She is currently an elected counselor for the National Academy of Science,^[5] a member of the American Academy of Arts and Sciences and the United States National Academy of Sciences, serves on the National Institutes of Health working group for the BRAIN Initiative, and is a former president of the Society for Neuroscience.^[6] She is also a Deputy Editor at eLife,^[7] and, due to her early interest in politics, she often writes about science, politics, and society.^[8] In 1990 at Brandeis, she established one of the first undergraduate neuroscience programs in the United States.^[9]

Select publications[]

Scholia has a profile for Eve Marder (Q5416184).

Eve Marder has an extensive publication record in the areas of neuromodulation, computational neuroscience, the dynamics of small networks, and neuropeptides. A selection of works are listed below:

• Marder, E.; Calabrese, R. L. (1996-07-01). "Principles of rhythmic motor pattern generation". Physiological Reviews. 76 (3): 687–717. doi:10.1152/physrev.1996.76.3.687. ISSN 0031-9333. PMID 8757786.
• Bucher, Dirk; Marder, Eve (2001-11-27). "Central pattern generators and the control of rhythmic movements". Current Biology. 11 (23): R986–R996. doi:10.1016/S0960-9822(01)00581-4. ISSN 0960-9822. PMID 11728329. S2CID 1294374.
• Marder, Eve; Bucher, Dirk; Prinz, Astrid A. (2004). "Similar network activity from disparate circuit parameters". Nature Neuroscience. 7 (12): 1345–1352. doi:10.1038/nn1352. ISSN 1546-1726. PMID 15558066. S2CID 6697491.
• Marder, E.; Abbott, L. F.; Turrigiano, G. (1994-05-13). "Activity-dependent changes in the intrinsic properties of cultured neurons". Science. 264 (5161): 974–977. Bibcode:1994Sci...264..974T. doi:10.1126/science.8178157. ISSN 0036-8075. PMID 8178157.
• Sharp, A. A.; O'Neil, M. B.; Abbott, L. F.; Marder, E. (1993-03-01). "Dynamic clamp: computer-generated conductances in real neurons". Journal of Neurophysiology. 69 (3): 992–995. doi:10.1152/jn.1993.69.3.992. ISSN 0022-3077. PMID 8463821.
• Marder, Eve; Goaillard, Jean-Marc; Schulz, David J. (2006). "Variable channel expression in identified single and electrically coupled neurons in different animals". Nature Neuroscience. 9 (3): 356–362. doi:10.1038/nn1639. ISSN 1546-1726. PMID 16444270. S2CID 19657439.
• Marder, Eve; Wood, Debra; Swensen, Andrew M.; Blitz, Dawn M.; Nusbaum, Michael P. (2001-03-01). "The roles of co-transmission in neural network modulation". Trends in Neurosciences. 24 (3): 146–154. doi:10.1016/S0166-2236(00)01723-9. ISSN 0166-2236. PMID 11182454. S2CID 8994646.

Notable awards[]

• National Academy of Science Award in the Neurosciences (2019)^[10]
• Honorary Doctorate from Tel Aviv University (2017)^[11]
• Kavli Prize in Neuroscience (2016)^[12]
• Gruber Neuroscience Prize (2013)^[13]
• Member, Institute of Medicine (2013)
• George A. Miller Prize, Cognitive Neuroscience Society (2012)^[14]
• Karl Spenser Lashley Prize, American Philosophical Society (2012)^[15]
• Honorary Doctor of Science, Bowdoin College (2010)
• Fellow, Biophysical Society (2008)
• Member, National Academy of Sciences (2007)
• President, Society for Neuroscience (2007)^[16]
• President-Elect, Society for Neuroscience (2006–2007)
• Gerard Prize, Society for Neuroscience (2005)
• Trustee of the Grass Foundation (2002–2005)
• Women in Neuroscience Mika Salpeter Lifetime Achievement Award (2002–2003)
• Fellow, American Academy of Arts and Sciences (2001–2001)
• MERIT (Method to Extend Research in Time) Award, National Institutes of Health (1995–2000)
• McKnight Endowment fund for Neuroscience Investigator Award (1994)
• Jacob Javits Neuroscience Investigator Award, National Advisory Neurological and Communicative Disorders and Stroke Council (1987–1994)

References[]

External links[]

• Brandeis Marder page
• Eve Marder iBioseminars: "Understanding Circuit Dynamics"