FYB

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FYB1

Protein FYB PDB 1ri9.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1RI9, 2GTJ, 2GTO

Identifiers

FYB1, ADAP, PRO0823, SLAP-130, SLAP130, FYB, FYN binding protein, THC3, FYN binding protein 1

External IDs

OMIM: 602731 MGI: 1346327 HomoloGene: 22664 GeneCards: FYB1

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5p13.1	Start	39,105,252 bp^[1]
Band	5p13.1	End	39,274,528 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 A1	Start	6,552,334 bp^[2]
Band	15\|15 A1	End	6,692,794 bp^[2]

RNA expression pattern

Top expressed in
blood bone marrow appendix lymph node spleen cancellous bone thymus lung occipital lobe visceral pleura
More reference expression data


More reference expression data

Gene ontology
Molecular function	signaling receptor binding GO:0001948 protein binding lipid binding GO:0032403 protein-containing complex binding
Cellular component	cytoplasm cytosol nucleus actin cytoskeleton plasma membrane cell junction
Biological process	protein phosphorylation GO:0007243 intracellular signal transduction protein localization to plasma membrane T cell receptor signaling pathway immune response signal transduction NLS-bearing protein import into nucleus biological process integrin-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


2533


23880

Ensembl


ENSG00000082074


ENSMUSG00000022148


O15117


O35601

RefSeq (mRNA)


NM_001243093 NM_001465 NM_199335 NM_001349333 NM_018594


NM_001278269 NM_011815

RefSeq (protein)


NP_001230022 NP_001456 NP_955367 NP_001336262 NP_061064


NP_001265198 NP_035945

Location (UCSC)

Chr 5: 39.11 – 39.27 Mb

Chr 15: 6.55 – 6.69 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

FYN binding protein (FYB-120/130), also known as FYB, ADAP (Adhesion- and Degranulation-promoting Adapter Protein), and SLAP-130 (SLP-76-associated phosphoprotein of 130 kDa) is a protein that in humans is encoded by the FYB gene.^[5]

Interactions[]

FYB has been shown to interact with:

FYN,^[6]^[7]
SLP-76 (Lymphocyte cytosolic protein 2),^[8] and
SKAP1.^[7]^[9]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082074 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022148 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FYB FYN binding protein (FYB-120/130)".
^ da Silva AJ, Janssen O, Rudd CE (Dec 1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. doi:10.1084/jem.178.6.2107. PMC 2191307. PMID 7504057.
^ ^a ^b Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (Oct 1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.
^ Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. doi:10.1074/jbc.272.18.11674. PMID 9115214.
^ Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (Jul 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.

Further reading[]

da Silva AJ, Janssen O, Rudd CE (1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. doi:10.1084/jem.178.6.2107. PMC 2191307. PMID 7504057.
Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. doi:10.1074/jbc.272.18.11674. PMID 9115214.
da Silva AJ, Li Z, de Vera C, Canto E, Findell P, Rudd CE (1997). "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7493–8. Bibcode:1997PNAS...94.7493D. doi:10.1073/pnas.94.14.7493. PMC 23849. PMID 9207119.
Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.
Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.
Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. S2CID 37288744.
Veale M, Raab M, Li Z, da Silva AJ, Kraeft SK, Weremowicz S, Morton CC, Rudd CE (1999). "Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production". J. Biol. Chem. 274 (40): 28427–35. doi:10.1074/jbc.274.40.28427. PMID 10497204.
Hamid N, Gustavsson A, Andersson K, McGee K, Persson C, Rudd CE, Fällman M (1999). "YopH dephosphorylates Cas and Fyn-binding protein in macrophages". Microbial Pathogenesis. 27 (4): 231–42. doi:10.1006/mpat.1999.0301. PMID 10502464.
Geng L, Raab M, Rudd CE (1999). "Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651". J. Immunol. 163 (11): 5753–7. PMID 10570256.
Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE (2000). "SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55". EMBO J. 19 (12): 2889–99. doi:10.1093/emboj/19.12.2889. PMC 203341. PMID 10856234.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". J. Biol. Chem. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.
Li C, Iosef C, Jia CY, Han VK, Li SS (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Heuer K, Arbuzova A, Strauss H, Kofler M, Freund C (2005). "The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain". J. Mol. Biol. 348 (4): 1025–35. doi:10.1016/j.jmb.2005.02.069. PMID 15843031.
Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL (2005). "Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells". J. Biol. Chem. 280 (25): 23576–83. doi:10.1074/jbc.M413201200. PMID 15849195.
Koga S, Yogo K, Yoshikawa K, Samori H, Goto M, Uchida T, Ishida N, Takeya T (2005). "Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro". J. Biol. Chem. 280 (36): 31564–71. doi:10.1074/jbc.M502703200. PMID 16020549.
Duke-Cohan JS, Kang H, Liu H, Rudd CE (2006). "Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein". J. Biol. Chem. 281 (19): 13743–50. doi:10.1074/jbc.M508774200. PMID 16461356.

v t PDB gallery
1ri9: Structure of a helically extended SH3 domain of the T cell adapter protein ADAP 2gtj: Reduced form of ADAP hSH3-N-domain 2gto: Oxidized form of ADAP hSH3-N

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