Farnesyl-diphosphate farnesyltransferase 1
Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. [5]
Function[]
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.
References[]
- ^ a b c ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021273 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Retrieved 2016-06-25.
Further reading[]
- Kavanagh KL, Guo K, Dunford JE, Wu X, Knapp S, Ebetino FH, Rogers MJ, Russell RG, Oppermann U (2006). "The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7829–34. Bibcode:2006PNAS..103.7829K. doi:10.1073/pnas.0601643103. PMC 1472530. PMID 16684881.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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