Fetal trimethadione syndrome

Classification	D ICD-10: Q86.8; MeSH: C537798;
External resources	Orphanet: 1913;

Fetal trimethadione syndrome
Fetal trimethadione syndrome
Other names	German syndrome
	Condition is caused by Trimethadione (and paramethadione)

Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others^[1]) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.^[2]

Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,^[3] meaning it affects less than 200,000 individuals in the United States.^[4]

The fetal loss rate while using trimethadione has been reported to be as high as 87%.^[5]

Presentation[]

Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.^[2]^[6]

Cranial and facial abnormalities which include; microcephaly, flattening, V-shaped eyebrows and a short nose
Cardiovascular abnormalities
Absent kidney and ureter
Meningocele, a birth defect of the spine
Omphalocele, a birth defect where portions of the abdominal contents project into the umbilical cord
A delay in mental and physical development

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Diagnosis[]

Treatment[]

References[]

^ Additional names include trimethadione embryopathy and trimethadione syndrome.
^ Jump up to: ^a ^b Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
^ Fetal trimethadione syndrome on the ORD website. Retrieved January 2007
^ NIH's Office of Rare Diseases Archived 2009-02-06 at the Wayback Machine Retrieved January 2007
^ Teratology and Drug Use During Pregnancy Retrieved January 2007
^ The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007

External links[]

[1] Additional names include trimethadione embryopathy and trimethadione syndrome.

[nlm.nih.gov-2] Jump up to: ^a ^b Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007

[3] Fetal trimethadione syndrome on the ORD website. Retrieved January 2007

[4] NIH's Office of Rare Diseases Archived 2009-02-06 at the Wayback Machine Retrieved January 2007

[5] Teratology and Drug Use During Pregnancy Retrieved January 2007

[6] The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007

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Classification	D ICD-10: Q86.8 MeSH: C537798
External resources	Orphanet: 1913