Firazorexton

Firazorexton
Identifiers
	IUPAC name N-[(2S,3S)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]methanesulfonamide;
CAS Number	2274802-95-6 ;
PubChem CID	137460733;
UNII	U9MOX60GHD;
Chemical and physical data
Formula	C22H25F3N2O4S
Molar mass	470.51 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C(=O)N1CC[C@@H]([C@@H]1CC2=C(C(=CC=C2)C3=CC(=CC(=C3)F)F)F)NS(=O)(=O)C)O;
	InChI InChI=1S/C22H25F3N2O4S/c1-22(2,29)21(28)27-8-7-18(26-32(3,30)31)19(27)11-13-5-4-6-17(20(13)25)14-9-15(23)12-16(24)10-14/h4-6,9-10,12,18-19,26,29H,7-8,11H2,1-3H3/t18-,19-/m0/s1; Key:VOSAWOSMGPKQEQ-OALUTQOASA-N;

Firazorexton (INN) is an experimental orexin 2 (OX₂) receptor agonist first described in a 2019 patent filed by Takeda Pharmaceutical Company.^[1]^[2]

References[]

^ "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). WHO Drug Information. 34 (1): 93–269. 2020. Proposed INN: List 123
^ WO application 2019027058, Kajita Y, Mikami S, Miyanohana Y, Koike T, Daini M, Oyabu N, Ogino M, Takeuchi K, Ito Y, Tokunaga N, Sugimoto T, Miyazaki T, Oda T, Hoashi Y, Hattori Y, Imamura K, "Heterocyclic compound and use therof", published 2019-02-07, assigned to Takeda Pharmaceutical Company

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v t Orexin receptor modulators
OX₁	Agonists: Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant Daridorexant Filorexant GSK-649868 (SB-649868) Lemborexant RTIOX-276 SB-334867 SB-408124 Suvorexant Vornorexant (ORN-0829, TS-142)
OX₂	Agonists: Danavorexton (TAK-925) Firazorexton Orexin (A, B) Suntinorexton TAK-994 Antagonists: ACT-335827 ACT-462206 Almorexant Daridorexant EMPA Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant Seltorexant Suvorexant TCS-OX2-29 Vornorexant (ORN-0829, TS-142)

Identifiers

IUPAC name N-[(2S,3S)-2-[[3-(3,5-difluorophenyl)-2-fluorophenyl]methyl]-1-(2-hydroxy-2-methylpropanoyl)pyrrolidin-3-yl]methanesulfonamide
CAS Number	2274802-95-6^Y
PubChem CID	137460733
UNII	U9MOX60GHD
Chemical and physical data
Formula	C₂₂H₂₅F₃N₂O₄S
Molar mass	470.51 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)(C(=O)N1CC[C@@H]([C@@H]1CC2=C(C(=CC=C2)C3=CC(=CC(=C3)F)F)F)NS(=O)(=O)C)O
InChI InChI=1S/C22H25F3N2O4S/c1-22(2,29)21(28)27-8-7-18(26-32(3,30)31)19(27)11-13-5-4-6-17(20(13)25)14-9-15(23)12-16(24)10-14/h4-6,9-10,12,18-19,26,29H,7-8,11H2,1-3H3/t18-,19-/m0/s1 Key:VOSAWOSMGPKQEQ-OALUTQOASA-N