Frederick Alt
Frederick Alt | |
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Other names | Fred Alt |
Alma mater | |
Scientific career | |
Institutions | |
Doctoral students | Karen M. Frank |
Frederick "Fred" W. Alt is an American geneticist. He is a member of the Immunology section of the National Academy of Sciences and a Charles A. Janeway Professor of Pediatrics, and Professor of Genetics at Harvard Medical School.[1] He is the Director of the Program in Cellular and Molecular Medicine at the Boston Children's Hospital.[2] He is a Howard Hughes Medical Institute investigator, since 1987.
Career[]
He completed his undergraduate studies at Brandeis University, graduating in 1971.[3] He then went on to earn a Ph.D. in Biology from Stanford University in 1977 while under the research direction of Robert Schimke.[citation needed] He performed his postdoctoral work in David Baltimore's laboratory at Massachusetts Institute of Technology (MIT).[citation needed] From 1982 to 1991 he was on the faculty at Columbia University and then moved to Harvard Medical School.[4]
His research interest is in maintenance of genome stability in cells of the mammalian immunological system, particularly antigen receptor variable region gene assembly in developing B and T lymphocytes, immunoglobulin heavy chain class switch recombination (CSR), and somatic hypermutation in activated mature B lymphocytes.[1]
Personal life[]
He is the father of the chef and food writer, J. Kenji López-Alt.[5]
Awards, memberships and honors[]
He has received many awards, this is a select list:
- Clowes Memorial Award from the American Association for Cancer Research
- Rabbi Shai Shacknai Prize from The Hebrew University
- Pasarow Foundation Prize for Extraordinary Achievement in Cancer Research
- Leukemia & Lymphoma Society de Villiers International Achievement Award
- Irvington Institute Immunology Award
- National Cancer Institute Alfred K. Knudson Award for pioneering contributions that have revolutionized the field of Cancer Genetics
- AAI-Huang Meritorious Career Award, American Association of Immunologists
- Excellence in Mentoring Award, American Association of Immunologists.
- 2007 – Novartis Prize for Basic Immunology for his discoveries on B cell development and antigen responses[6]
- 2009 – William B. Coley Award for New Discoveries in Immunology from the Cancer Research Institute[7]
- 2014 – 44th annual Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research[3]
- 2015 – Szent-Györgyi Prize for Progress in Cancer Research, from the National Foundation for Cancer Research (NFCR)[8]
- 2019 – BioLegend Herzenberg Award, for "exemplary research contributions to the field of B cell biology", American Association of Immunologists.[9][10]
The Cancer Research Institute of New York gives an annual prize in his honor, the Frederick W. Alt Award for New Discoveries in Immunology.
Alt is a member of:
- U.S. National Academy of Sciences
- American Academy of Arts and Sciences
- American Academy of Microbiology
References[]
- ^ Jump up to: a b Dana-Farber profile
- ^ "How new loops in DNA packaging help us make diverse antibodies". phys.org. Retrieved 2019-11-14.
- ^ Jump up to: a b "Pioneering geneticist Frederick Alt '71 wins 44th Rosenstiel Award". BrandeisNOW. Retrieved 2019-11-14.
- ^ "Children's Hospital bio". Archived from the original on 2018-01-20. Retrieved 2011-09-10.
- ^ Robertson, Blair Anthony (2015). "Science becomes delicious in 'The Food Lab'". The Sacramento Bee. Archived from the original on 2015-12-16. Retrieved 2019-11-13.
His father, Frederick Alt, is a professor at Harvard Medical School
- ^ "Laureates". Novartis Prizes for Immunology. 2018-08-29. Archived from the original on 2018-08-29. Retrieved 2019-11-14.
- ^ "CRI Announces Winner of 2009 Frederick Alt Award for New Discoveries in Immunology". Cancer Research Institute. Retrieved 2019-11-14.
- ^ Scully, Peter; Zhao, Jie; Ba, Sujuan (2016-02-03). "Frederick W. Alt received the 2015 Szent-Györgi Prize for Progress in Cancer Research". Chinese Journal of Cancer. 35: 17. doi:10.1186/s40880-015-0075-x. ISSN 1000-467X. PMC 4741029. PMID 26843073.
- ^ "AAI-BioLegend Herzenberg Award". The American Association of Immunologists, Inc. (AAI).
- ^ "AAI Career Awards". Immunology 2019. Retrieved 2019-11-14.
External links[]
- American geneticists
- Harvard Medical School faculty
- Living people
- Stanford University School of Humanities and Sciences alumni
- Members of the United States National Academy of Sciences
- Howard Hughes Medical Investigators
- Fellows of the American Academy of Microbiology