GATAD2B

GATAD2B
Identifiers
Aliases	GATAD2B, MRD18, P66beta, p68, GATA zinc finger domain containing 2B, GANDS
External IDs	OMIM: 614998 MGI: 2443225 HomoloGene: 32484 GeneCards: GATAD2B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,923,360 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,270,714 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; quadriceps femoris muscle; ; prosencephalon; ; brain; ; internal globus pallidus; ; neocortex; ; cerebral cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; nucleosomal DNA binding; sequence-specific DNA binding; zinc ion binding; GO:0001948 protein binding; metal ion binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nuclear speck; nucleus; nucleoplasm; NuRD complex; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	57459
	229542
	ENSG00000143614; ENSG00000261992
	ENSMUSG00000042390
	Q8WXI9
	Q8VHR5
	NM_020699
	NM_139304; NM_001379655; NM_001379656; NM_001379657
	NP_065750
	NP_647465; NP_001366584; NP_001366585; NP_001366586
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.^[5]^[6]^[7]

Interactions[]

GATAD2B has been shown to interact with Methyl-CpG-binding domain protein 2,^[6]^[8] MBD3,^[6]^[8] RBBP7^[6] and RBBP4.^[6]

References[]

^ ^a ^b ^c ENSG00000261992 GRCh38: Ensembl release 89: ENSG00000143614, ENSG00000261992 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042390 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
^ ^a ^b ^c ^d ^e Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (Dec 2001). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol Cell Biol. 22 (2): 536–46. doi:10.1128/MCB.22.2.536-546.2002. PMC 139742. PMID 11756549.
^ "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B".
^ ^a ^b Brackertz, Marc; Boeke Joern; Zhang Ru; Renkawitz Rainer (Oct 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. United States. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. ISSN 0021-9258. PMID 12183469.

Further reading[]

Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Brackertz M, Gong Z, Leers J, Renkawitz R (2006). "p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction". Nucleic Acids Res. 34 (2): 397–406. doi:10.1093/nar/gkj437. PMC 1331983. PMID 16415179.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000261992 GRCh38: Ensembl release 89: ENSG00000143614, ENSG00000261992 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042390 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574461-5] Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.

[pmid11756549-6] Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (Dec 2001). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol Cell Biol. 22 (2): 536–46. doi:10.1128/MCB.22.2.536-546.2002. PMC 139742. PMID 11756549.

[entrez-7] "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B".

[pmid12183469-8] Brackertz, Marc; Boeke Joern; Zhang Ru; Renkawitz Rainer (Oct 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. United States. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. ISSN 0021-9258. PMID 12183469.

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