GGA3

GGA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JPL, 1JUQ, 1LF8, 1P4U, 1WR6, 1YD8
Identifiers
Aliases	GGA3, golgi associated, gamma adaptin ear containing, ARF binding protein 3
External IDs	OMIM: 606006 MGI: 2384159 HomoloGene: 121703 GeneCards: GGA3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,262,363 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,494,877 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; lymph node; ; pylorus; ; spleen; ; stomach; ; gastric mucosa;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; ubiquitin binding;
Cellular component	endosome; trans-Golgi network; endosome membrane; intracellular anatomical structure; membrane; clathrin adaptor complex; Golgi apparatus; early endosome membrane; recycling endosome membrane; early endosome; recycling endosome;
Biological process	protein transport; cellular protein metabolic process; intracellular protein transport; positive regulation of protein catabolic process; vesicle-mediated transport; protein localization to lysosome; regulation of protein stability; protein destabilization; endocytic recycling; protein localization to cell surface; Golgi to plasma membrane protein transport; negative regulation of amyloid-beta formation;
	Sources:Amigo / QuickGO
Orthologs
	23163
	260302
	ENSG00000125447
	ENSMUSG00000020740
	Q9NZ52
	Q8BMI3
NM_001172703; NM_001172704; NM_001291641; NM_001291642; NM_014001;
	NM_138619
	NM_001252067; NM_173048
NP_001166174; NP_001166175; NP_001278570; NP_001278571; NP_054720;
	NP_619525
	NP_001238996; NP_766636
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene.^[5]^[6]

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Alternative splicing of this gene results in two transcript variants.^[7]

Interactions[]

GGA3 has been shown to interact with ARF1^[5]^[8] and ARF3.^[6]^[9]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125447 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020740 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". The Journal of Cell Biology. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.
^ ^a ^b Boman AL, Zhang C, Zhu X, Kahn RA (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.
^ "Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3".
^ Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
^ Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.

Further reading[]

Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (April 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". The Journal of Cell Biology. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochemical and Biophysical Research Communications. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.
Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS (June 2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science. 292 (5522): 1712–6. Bibcode:2001Sci...292.1712P. doi:10.1126/science.1060750. PMID 11387475. S2CID 30836125.
Misra S, Puertollano R, Kato Y, Bonifacino JS, Hurley JH (February 2002). "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains". Nature. 415 (6874): 933–7. Bibcode:2002Natur.415..933M. doi:10.1038/415933a. PMID 11859375. S2CID 4430757.
Takatsu H, Yoshino K, Toda K, Nakayama K (July 2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". The Biochemical Journal. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392.
Kato Y, Misra S, Puertollano R, Hurley JH, Bonifacino JS (July 2002). "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism". Nature Structural Biology. 9 (7): 532–6. doi:10.1038/nsb807. PMID 12032548. S2CID 23740463.
Doray B, Bruns K, Ghosh P, Kornfeld SA (June 2002). "Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8072–7. Bibcode:2002PNAS...99.8072D. doi:10.1073/pnas.082235699. PMC 123022. PMID 12060753.
Wasiak S, Legendre-Guillemin V, Puertollano R, Blondeau F, Girard M, de Heuvel E, Boismenu D, Bell AW, Bonifacino JS, McPherson PS (September 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". The Journal of Cell Biology. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833.
Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S (September 2002). "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network". Science. 297 (5587): 1700–3. Bibcode:2002Sci...297.1700D. doi:10.1126/science.1075327. PMID 12215646. S2CID 8810528.
Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.
Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (January 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
Wakasugi M, Waguri S, Kametaka S, Tomiyama Y, Kanamori S, Shiba Y, Nakayama K, Uchiyama Y (July 2003). "Predominant expression of the short form of GGA3 in human cell lines and tissues". Biochemical and Biophysical Research Communications. 306 (3): 687–92. doi:10.1016/S0006-291X(03)01032-5. PMID 12810073.
He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J (October 2003). "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins". Biochemistry. 42 (42): 12174–80. doi:10.1021/bi035199h. PMID 14567678.
Ghosh P, Griffith J, Geuze HJ, Kornfeld S (November 2003). "Mammalian GGAs act together to sort mannose 6-phosphate receptors". The Journal of Cell Biology. 163 (4): 755–66. doi:10.1083/jcb.200308038. PMC 2173681. PMID 14638859.
Shiba Y, Katoh Y, Shiba T, Yoshino K, Takatsu H, Kobayashi H, Shin HW, Wakatsuki S, Nakayama K (February 2004). "GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination". The Journal of Biological Chemistry. 279 (8): 7105–11. doi:10.1074/jbc.M311702200. PMID 14660606.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125447 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020740 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10747089-5] Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, Hartnell LM, Bonifacino JS (April 2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". The Journal of Cell Biology. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089.

[pmid10749927-6] Boman AL, Zhang C, Zhu X, Kahn RA (April 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Molecular Biology of the Cell. 11 (4): 1241–55. doi:10.1091/mbc.11.4.1241. PMC 14844. PMID 10749927.

[entrez-7] "Entrez Gene: GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3".

[pmid11301005-8] Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS (April 2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell. 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005. S2CID 1158816.

[pmid12221117-9] Boman AL, Salo PD, Hauglund MJ, Strand NL, Rensink SJ, Zhdankina O (September 2002). "ADP-ribosylation factor (ARF) interaction is not sufficient for yeast GGA protein function or localization". Molecular Biology of the Cell. 13 (9): 3078–95. doi:10.1091/mbc.E02-02-0078. PMC 124144. PMID 12221117.

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