GMDS (gene)

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GMDS

Protein GMDS PDB 1t2a.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1T2A

Identifiers

GMDS, GMD, SDR3E1, GDP-mannose 4,6-dehydratase

External IDs

OMIM: 602884 MGI: 1891112 HomoloGene: 75968 GeneCards: GMDS

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p25.3	Start	1,623,806 bp^[1]
Band	6p25.3	End	2,245,605 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 A3.2	Start	32,003,562 bp^[2]
Band	13\|13 A3.2	End	32,522,723 bp^[2]

RNA expression pattern

Top expressed in
parotid gland salivary gland stomach thoracic aorta minor salivary gland duodenum
More reference expression data


More reference expression data

Gene ontology
Molecular function	GO:0001948 protein binding NADP+ binding lyase activity GDP-mannose 4,6-dehydratase activity identical protein binding
Cellular component	cytosol extracellular exosome cytoplasm
Biological process	GDP-mannose metabolic process 'de novo' GDP-L-fucose biosynthetic process Notch signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


2762


218138

Ensembl


ENSG00000112699


ENSMUSG00000038372


O60547


Q8K0C9

RefSeq (mRNA)


NM_001253846 NM_001500


NM_146041

RefSeq (protein)


NP_001240775 NP_001491


NP_666153

Location (UCSC)

Chr 6: 1.62 – 2.25 Mb

Chr 13: 32 – 32.52 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.^[5]^[6]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112699 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038372 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA (May 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

Further reading[]

Ohyama C, Smith PL, Angata K, et al. (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi:10.1074/jbc.273.23.14582. PMID 9603974.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi:10.1074/jbc.M107927200. PMID 11698403.
Eshel R, Besser M, Zanin A, et al. (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID 11831876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

v t PDB gallery
1t2a: Crystal structure of human GDP-D-mannose 4,6-dehydratase

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