GPHB5

From Wikipedia, the free encyclopedia

GPHB5

Identifiers

GPHB5, B5, GPB5, ZLUT1, glycoprotein hormone beta 5, glycoprotein hormone subunit beta 5

External IDs

OMIM: 609652 MGI: 2156540 HomoloGene: 18476 GeneCards: GPHB5

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q23.2	Start	63,312,835 bp^[1]
Band	14q23.2	End	63,318,935 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 C3	Start	75,458,496 bp^[2]
Band	12\|12 C3	End	75,463,555 bp^[2]

RNA expression pattern

Top expressed in
organ system lung brain prosencephalon neocortex Right lobe of liver dorsolateral prefrontal cortex pancreas
More reference expression data

n/a

Gene ontology
Molecular function	hormone activity thyrotropin-releasing hormone receptor binding protein heterodimerization activity GO:0001948 protein binding
Cellular component	extracellular region extracellular space cytoplasm
Biological process	regulation of thyroid hormone mediated signaling pathway cell-cell signaling hormone-mediated signaling pathway cell surface receptor signaling pathway regulation of signaling receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


122876


217674

Ensembl


ENSG00000179600


ENSMUSG00000048982


Q86YW7


Q812B2

RefSeq (mRNA)


NM_145171


NM_175644

RefSeq (protein)


NP_660154


NP_783575

Location (UCSC)

Chr 14: 63.31 – 63.32 Mb

Chr 12: 75.46 – 75.46 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Glycoprotein hormone beta-5 is a protein that in humans is encoded by the GPHB5 gene.^[5]

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM]^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179600 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048982 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GPHB5 glycoprotein hormone beta 5".

Further reading[]

Okada SL, Ellsworth JL, Durnam DM, et al. (2006). "A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor". Mol. Endocrinol. 20 (2): 414–25. doi:10.1210/me.2005-0270. PMID 16210345.
Sudo S, Kuwabara Y, Park JI, et al. (2005). "Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5". Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hsu SY, Nakabayashi K, Bhalla A (2003). "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5". Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/me.16.7.1538. PMID 12089349.
Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor". J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.

This protein-related article is a stub. You can help Wikipedia by .

Retrieved from ""

Categories:

Genes on human chromosome 14
Human proteins
Protein stubs

Hidden categories:

All stub articles