GPSM1

GPSM1
Identifiers
Aliases	GPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDs	OMIM: 609491 MGI: 1915089 HomoloGene: 16987 GeneCards: GPSM1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,359,605 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,238,249 bp
RNA expression pattern
	Top expressed in
	tibia; ; retinal pigment epithelium; ; cerebellar vermis; ; cerebellar hemisphere; ; left ventricle; ; neocortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; GO:0005083 GTPase regulator activity; GDP-dissociation inhibitor activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; endoplasmic reticulum; membrane; Golgi membrane; endoplasmic reticulum membrane; plasma membrane; cell cortex; protein-containing complex;
Biological process	multicellular organism development; cell differentiation; nervous system development; positive regulation of macroautophagy; GO:0034259 negative regulation of GTPase activity; negative regulation of guanyl-nucleotide exchange factor activity;
	Sources:Amigo / QuickGO
Orthologs
	26086
	67839
	ENSG00000160360
	ENSMUSG00000026930
	Q86YR5
	Q6IR34
	NM_001145638; NM_001145639; NM_001200003; NM_015597
NM_001199146; NM_001199147; NM_153410; NM_001355574; NM_001355575;
	NM_001355576
	NP_001139110; NP_001139111; NP_001186932; NP_056412
NP_001186075; NP_001186076; NP_700459; NP_001342503; NP_001342504;
	NP_001342505
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.^[5]^[6]^[7]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160360 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026930 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
^ Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
^ ^a ^b "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading[]

Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. doi:10.1074/jbc.M006478200. PMID 11024022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. doi:10.1074/jbc.M300917200. PMID 12642577.
Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. doi:10.1074/jbc.M306300200. PMID 14530282.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540. S2CID 12900159.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160360 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026930 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278352-5] Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.

[pmid10969064-6] Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.

[entrez-7] "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

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