GRB10

GRB10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HK0, 1NRV
Identifiers
Aliases	GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
External IDs	OMIM: 601523 MGI: 103232 HomoloGene: 3882 GeneCards: GRB10
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.1 Start 50,590,063 bp[1] End 50,793,462 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 7.15 cM Start 11,930,508 bp[2] End 12,038,683 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • insulin receptor binding • identical protein binding Cellular component • cytoplasm • cytosol • plasma membrane • protein-containing complex Biological process • response to insulin • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • insulin-like growth factor receptor signaling pathway • negative regulation of phosphorylation • positive regulation of phosphorylation • negative regulation of glycogen biosynthetic process • signal transduction • insulin receptor signaling pathway • axon guidance • negative regulation of Wnt signaling pathway • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2887	14783
Ensembl	ENSG00000106070	ENSMUSG00000020176
UniProt	Q13322	Q60760
RefSeq (mRNA)	NM_001001549 NM_001001550 NM_001001555 NM_005311 NM_001350814 NM_001350815 NM_001350816 NM_001371008 NM_001371009	NM_001177629 NM_010345 NM_001370603
RefSeq (protein)	NP_001001549 NP_001001550 NP_001001555 NP_001337743 NP_001337744 NP_001337745 NP_001357937 NP_001357938	NP_001171100 NP_034475 NP_001357532
Location (UCSC)	Chr 7: 50.59 – 50.79 Mb	Chr 11: 11.93 – 12.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.^[5][6][7][8]

Function[]

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Animal studies[]

Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.^[9]

Interactions[]

GRB10 has been shown to interact with

• Abl gene,^[10][11]
• BCR gene,^[10]
• C-Raf,^[12][13]
• c-Kit,^[14]
• Insulin receptor,^{[11][15][16][17][18]}
• Insulin-like growth factor 1 receptor,^{[18][19][20][21]}
• MAP2K1,^[13] and
• RET proto-oncogene.^[22]

References[]

Further reading[]

External links[]

• GRB10+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.