GRIK3

GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	OMIM: 138243 MGI: 95816 HomoloGene: 73901 GeneCards: GRIK3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,034,515 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,714,173 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• kainate selective glutamate receptor activity; • adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; • ion channel activity; • extracellularly glutamate-gated ion channel activity; • ligand-gated ion channel activity; • ionotropic glutamate receptor activity; • G protein-coupled receptor binding; • glutamate receptor activity; • signaling receptor activity; • ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	• integral component of membrane; • postsynaptic membrane; • membrane; • plasma membrane; • synapse; • integral component of plasma membrane; • cell junction; • dendrite cytoplasm; • perikaryon; • dendrite; • terminal bouton; • axon; • kainate selective glutamate receptor complex; • presynaptic membrane; • glutamatergic synapse;
Biological process	• G protein-coupled glutamate receptor signaling pathway; • glutamate receptor signaling pathway; • ion transport; • ion transmembrane transport; • negative regulation of synaptic transmission, glutamatergic; • ionotropic glutamate receptor signaling pathway; • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; • regulation of membrane potential; • excitatory postsynaptic potential; • synaptic transmission, glutamatergic; • modulation of chemical synaptic transmission; • regulation of presynaptic membrane potential; • regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2899
	14807
	ENSG00000163873
	ENSMUSG00000001985
	Q13003
	B1AS29
	NM_000831
	NM_001081097
	NP_000822
	NP_001074566
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.^[5]^[6]

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163873 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001985 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (Apr 1994). "Chromosomal localization of gene for human glutamate receptor subunit-7". Somat Cell Mol Genet. 19 (6): 581–8. doi:10.1007/BF01233385. PMID 8128318. S2CID 44460126.
^ ^a ^b "Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3".

External links[]

GRIK3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163873 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001985 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8128318-5] Puranam RS, Eubanks JH, Heinemann SF, McNamara JO (Apr 1994). "Chromosomal localization of gene for human glutamate receptor subunit-7". Somat Cell Mol Genet. 19 (6): 581–8. doi:10.1007/BF01233385. PMID 8128318. S2CID 44460126.

[entrez-6] "Entrez Gene: GRIK3 glutamate receptor, ionotropic, kainate 3".

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GRIK3

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