Granzyme K is a protein that in humans is encoded by the GZMKgene.[5][6]
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.[6]
Hameed A, Lowrey DM, Lichtenheld M, Podack ER (1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J. Immunol. 141 (9): 3142–7. PMID3262682.
Baker E, Sayers TJ, Sutherland GR, Smyth MJ (1994). "The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases". Immunogenetics. 40 (3): 235–7. doi:10.1007/BF00167085. PMID8039831. S2CID37615055.
Sayers TJ, Lloyd AR, McVicar DW, et al. (1996). "Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3". J. Leukoc. Biol. 59 (5): 763–8. doi:10.1002/jlb.59.5.763. PMID8656064. S2CID18065724.
Zhao T, Zhang H, Guo Y, et al. (2007). "Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells". Cell Death Differ. 14 (3): 489–99. doi:10.1038/sj.cdd.4402040. PMID17008916. S2CID6044972.
Rucevic M, Fast LD, Jay GD, et al. (2007). "Altered levels and molecular forms of granzyme k in plasma from septic patients". Shock. 27 (5): 488–93. doi:10.1097/01.shk.0000246905.24895.e5. PMID17438453. S2CID525904.
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PDB gallery
1mza: crystal structure of human pro-granzyme K
1mzd: crystal structure of human pro-granzyme K
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