Glutaurine

From Wikipedia, the free encyclopedia
Glutaurine
Glutaurine.svg
Names
IUPAC name
N5-(2-Sulfoethyl)-L-glutamine
Preferred IUPAC name
(2S)-2-Amino-5-oxo-5-[(2-sulfoethyl)amino]pentanoic acid
Other names
γ-Glutamyltaurine; γ-GT; γ-L-Glutamyltaurine[1]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
UNII
Properties
C7H14N2O6S
Molar mass 173.1897
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Glutaurine is an endogenous dipeptide which is an amide formed from glutamic acid and taurine.

Biological role[]

Glutaurine is an antiepileptic with antiamnesia properties.[medical citation needed] Glutaurine was discovered in the parathyroid in 1980, and later in the mammalian brain. This led to studies on intrinsic and synthetic taurine peptides, and the suggestion that γ-glutamyltransferase (GGT; γ-glutamyl-transpeptidase) in the brain is responsible for its in vivo formation.[2]

The versatile molecule mimics the anxiolytic drug diazepam, and is implicated in phenomena from feline aggression to amphibian metamorphosis, radiation protection, and the glutamatergic system in schizophrenic disorders.[2]

References[]

  1. ^ "56488-60-9 CAS Manufactory". Chemicalbook.com. Retrieved 2012-04-21.
  2. ^ Jump up to: a b Bittner, S.; Win, T.; Gupta, R. (2005). "γ-L-glutamyltaurine". Amino Acids. 28 (4): 343–356. doi:10.1007/s00726-005-0196-7. PMID 15838590. S2CID 209532290.
Retrieved from ""