H2AFJ

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H2AJ
Protein H2AFJ PDB 1aoi.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AJ, H2A histone family member J, H2AFJ, H2A.J histone
External IDsMGI: 3606192 HomoloGene: 128575 GeneCards: H2AJ
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018267
NM_177925

NM_177688

RefSeq (protein)

NP_808760

NP_808356

Location (UCSC)Chr 12: 14.77 – 14.78 MbChr 6: 136.79 – 136.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member.[5]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000246705 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060032 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: H2AFJ H2A histone family, member J".

Further reading[]


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