Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGHgene.[5][6][7]
The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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^Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet. 58 (4): 358–61. doi:10.1007/bf00282815. PMID7327557. S2CID10452468.
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Thornalley PJ, Bellavite P (1987). "Modification of the glyoxalase system during the functional activation of human neutrophils". Biochim. Biophys. Acta. 931 (2): 120–9. doi:10.1016/0167-4889(87)90198-4. PMID3663711.
Di Ilio C, Angelucci S, Pennelli A, et al. (1995). "Glyoxalase activities in tumor and non-tumor human urogenital tissues". Cancer Lett. 96 (2): 189–93. doi:10.1016/0304-3835(95)03928-P. PMID7585456.
Rulli A, Carli L, Romani R, et al. (2001). "Expression of glyoxalase I and II in normal and breast cancer tissues". Breast Cancer Res. Treat. 66 (1): 67–72. doi:10.1023/A:1010632919129. PMID11368412. S2CID10225506.
Scirè A, Saccucci F, Bertoli E, et al. (2002). "Effect of acidic phospholipids on the structural properties of recombinant cytosolic human glyoxalase II". Proteins. 48 (1): 126–33. doi:10.1002/prot.10149. PMID12012344. S2CID25251778.
Mearini E, Romani R, Mearini L, et al. (2002). "Differing expression of enzymes of the glyoxalase system in superficial and invasive bladder carcinomas". Eur. J. Cancer. 38 (14): 1946–50. doi:10.1016/S0959-8049(02)00236-8. PMID12204678.