HEPACAM2
HEPACAM2 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | HEPACAM2, MIKI, HEPACAM family member 2 | ||||||||||||||||||||||||
External IDs | OMIM: 614133 MGI: 2141520 HomoloGene: 18724 GeneCards: HEPACAM2 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 7: 93.19 – 93.23 Mb | Chr 6: 3.46 – 3.5 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. [5]
Function[]
This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.
Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000188175 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044156 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: HEPACAM family member 2". Retrieved 2017-09-13.
Further reading[]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Categories:
- Genes on human chromosome 7
- Human chromosome 7 gene stubs