HIST1H2AJ

H2AC14
Identifiers
Aliases	H2AC14, H2A/E, H2AFE, dJ160A22.4, histone cluster 1, H2aj, histone cluster 1 H2A family member j, H2A clustered histone 14, HIST1H2AJ
External IDs	OMIM: 602791 MGI: 2448309 HomoloGene: 88882 GeneCards: H2AC14
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,814,777 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,718,474 bp
RNA expression pattern
	Top expressed in
	stomach; ; colon; ; lung; ; kidney; ; heart; ; bone marrow; ; Achilles tendon; ; sural nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	chromatin organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8331
	319173
	ENSG00000276368
	ENSMUSG00000061991
	Q99878
	Q8CGP5
	NM_021066
	NM_175661
	NP_066544
	NP_783592
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene.^[5]^[6]^[7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000276368 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000061991 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H2AJ histone cluster 1, H2aj".