HNRPF

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HNRNPF

Protein HNRPF PDB 2db1.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2HGL, 2HGM, 2HGN, 2KFY, 2KG0, 2KG1, 3TFY

Identifiers

HNRNPF, HNRPF, OK/SW-cl.23, mcs94-1, heterogeneous nuclear ribonucleoprotein F

External IDs

OMIM: 601037 MGI: 2138741 HomoloGene: 21032 GeneCards: HNRNPF

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q11.21	Start	43,385,617 bp^[1]
Band	10q11.21	End	43,409,186 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 F1	Start	117,877,285 bp^[2]
Band	6\|6 F1	End	117,902,583 bp^[2]

RNA expression pattern

Top expressed in
lymph node thymus fallopian tube appendix urinary bladder stomach spleen testicle small intestine
More reference expression data

n/a

Gene ontology
Molecular function	TBP-class protein binding transcription factor binding GO:0001948 protein binding single-stranded RNA binding nucleic acid binding RNA binding
Cellular component	catalytic step 2 spliceosome spliceosomal complex membrane nucleus nucleoplasm cytosol plasma membrane
Biological process	mRNA splicing, via spliceosome regulation of RNA splicing mRNA processing RNA processing fibroblast growth factor receptor signaling pathway RNA splicing RNA metabolic process interleukin-12-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


3185


98758

Ensembl


ENSG00000169813


ENSMUSG00000042079


P52597


Q9Z2X1

RefSeq (mRNA)

NM_004966 NM_001098204 NM_001098205 NM_001098206 NM_001098207
NM_001098208

NM_001166427 NM_001166428 NM_001166429 NM_001166430 NM_001166431
NM_001166432 NM_133834

RefSeq (protein)

NP_001091674 NP_001091675 NP_001091676 NP_001091677 NP_001091678
NP_004957

NP_001159899 NP_001159900 NP_001159901 NP_001159902 NP_001159903
NP_001159904 NP_598595

Location (UCSC)

Chr 10: 43.39 – 43.41 Mb

Chr 6: 117.88 – 117.9 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.^[5]^[6]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport.

While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169813 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042079 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
^ ^a ^b "Entrez Gene: HNRPF heterogeneous nuclear ribonucleoprotein F".

Further reading[]

McDonald H, Smailus D, Jenkins H, et al. (1992). "Identification and characterization of a gene at D10S94 in the MEN2A region". Genomics. 13 (2): 344–8. doi:10.1016/0888-7543(92)90251-M. PMID 1351868.
Matunis MJ, Xing J, Dreyfuss G (1994). "The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization". Nucleic Acids Res. 22 (6): 1059–67. doi:10.1093/nar/22.6.1059. PMC 307930. PMID 7512260.
Gamberi C, Izaurralde E, Beisel C, Mattaj IW (1997). "Interaction between the human nuclear cap-binding protein complex and hnRNP F." Mol. Cell. Biol. 17 (5): 2587–97. doi:10.1128/MCB.17.5.2587. PMC 232108. PMID 9111328.
Chou MY, Rooke N, Turck CW, Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. 19 (1): 69–77. doi:10.1128/MCB.19.1.69. PMC 83866. PMID 9858532.
Honoré B, Vorum H, Baandrup U (1999). "hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization". FEBS Lett. 456 (2): 274–80. doi:10.1016/S0014-5793(99)00911-4. PMID 10456323. S2CID 7617501.
Yoshida T, Kokura K, Makino Y, et al. (2000). "Heterogeneous nuclear RNA-ribonucleoprotein F binds to DNA via an oligo(dG)-motif and is associated with RNA polymerase II". Genes Cells. 4 (12): 707–19. doi:10.1046/j.1365-2443.1999.00295.x. PMID 10620016. S2CID 31210778.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
Zhang Y, Lindblom T, Chang A, et al. (2001). "Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1". Gene. 257 (1): 33–43. doi:10.1016/S0378-1119(00)00372-3. PMID 11054566.
Veraldi KL, Arhin GK, Martincic K, et al. (2001). "hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells". Mol. Cell. Biol. 21 (4): 1228–38. doi:10.1128/MCB.21.4.1228-1238.2001. PMC 99576. PMID 11158309.
Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC 6757688. PMID 12388589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Honoré B, Baandrup U, Vorum H (2004). "Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues". Exp. Cell Res. 294 (1): 199–209. doi:10.1016/j.yexcr.2003.11.011. PMID 14980514.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.

v t PDB gallery
2db1: Solution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homolog 2hgl: NMR structure of the first qRRM domain of human hnRNP F 2hgn: NMR structure of the third qRRM domain of human hnRNP F

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