Herbert Gutfreund

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Herbert Gutfreund FRS (21 October 1921 – 21 March 2021), better known as Freddie Gutfreund, was a British biochemist of Austrian origin, and Emeritus Professor at the University of Bristol.[1] Gutfreund died in March 2021 at the age of 99.[2]

Early life and education[]

Gutfreund was born on 21 October 1921 in Vienna to a middle-class professional family, the son of Clara (Pisko) and Paul Gutfreund.[3] His father was a civil engineer, and on his mother's side there were several scientists including the physicist Karl Weissenberg.[4] He had all his early education in Vienna.[5] However, the political turmoil of the 1930s forced him to leave Austria for England after the Anschluss of 1938. He joined an agricultural training scheme and became an accomplished dairyman. His interest in physiology was stimulated by reading Principles of General Physiology[6] by William Bayliss and he was much influenced by it. He earned his doctorate at Cambridge.

Career[]

After several years at the National Institute for Research in Dairying in Shinfield, Berkshire, Gutfreund spent most of his career at the University of Bristol, where he worked on proteolytic enzymes, including chymotrypsin and trypsin,[7] and was especially active in using methods of studying fast reactions to study enzyme mechanisms. In this connection he developed and improved apparatus for that purpose.[8] He opposed the notion of metabolite channelling in glycolysis.[9]

Textbooks[]

Gutfreund is also known for his textbooks on various aspects of enzyme catalysis, including Enzymes: Physical Principles[10] and Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts.[11] He collaborated with John Edsall on the book Biothermodynamics: The Study of Biochemical Processes at Equilibrium .[12]

Honours[]

He was elected to the Royal Society in 1981.[13]

References[]

  1. ^ Bristol, University of. "Nobel Prizes and Fellowships - About the University - University of Bristol". Bris.ac.uk. Retrieved 1 November 2018.
  2. ^ Births, marriages and deaths, March 27, 2021 – GUTFREUND Professor Herbert (Freddie) Gutfreund FRS
  3. ^ 1992-93, 5. 6. (1992). The International Who's Who: 1992-93. ISBN 9780946653843.CS1 maint: numeric names: authors list (link)
  4. ^ Gutfreund, H. I was lucky, I was there at the right time. CMLS, Cell. Mol. Life Sci. 61, 1–3 (2004). https://doi.org/10.1007/s00018-003-3378-z
  5. ^ Gutfreund, Herbert (2007). "How I Became a Biochemist: An Honorary One!". IUBMB Life. 59 (11): 734–737. doi:10.1080/15216540701551775. PMID 17852567. S2CID 27847114.
  6. ^ Bayliss, William Maddock (1918). Principles of general physiology. London: Longmans Green & Co.
  7. ^ Gutfreund, H.; Sturtevant, J. M. (1956). "The Mechanism of Chymotrypsin-Catalyzed Reactions". Proceedings of the National Academy of Sciences. 42 (10): 719–728. Bibcode:1956PNAS...42..719G. doi:10.1073/pnas.42.10.719. PMC 528322. PMID 16589938.
  8. ^ Gutfreund H (1999). "Rapid-flow techniques and their contributions to enzymology". Trends in Biochemical Sciences. 24: 458–460.
  9. ^ Gutfreund H, Chock PB (1991). "Substrate channelling among glycolytic enzymes: fact or fiction". Journal of Theoretical Biology. 152 (1): 117–121. Bibcode:1991JThBi.152..117G. doi:10.1016/S0022-5193(05)80524-7. PMID 1753754.
  10. ^ Gutfreund H (1972). Enzymes: Physical Principles. Wiley-Blackwell.
  11. ^ Gutfreund H (1995). Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts. Cambridge University Press.
  12. ^ Edsall JT, Gutfreund H (1983). Biothermodynamics: The Study of Biochemical Processes at Equilibrium. Wiley-Blackwell.
  13. ^ "Herbert Gutfreund". Royal Society. 1 September 2015. Retrieved 10 October 2018.

External links[]

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