Hille equation

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The Hille equation relates the maximum ionic conductance of an ion channel to its length and radius (or diameter), with the commonly used version implicitly takes into account a hemispherical cap.[1] As it is ultimately based on a macroscopic continuum model, it does not take into account molecular interactions, and real conductances are often several times less than the predicted maximal flux.

Assumptions and Derivations[]

Equation[]

Parameters in the Hille equation.

The Hille equation predicts the following maximum conductance for a pore with length , radius , in a solvent with resistivity :

Rearranging the terms, the maximal flux based on length and diameter can be shown to be:

Physical Implications[]

References[]

  1. ^ Hille, Bertil (2001). Ion channels of excitable membranes'. Sunderland, MA: Sinauer Associates. ISBN 978-0-87893-321-1.
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