Hopeahainol A

Hopeahainol A
Names
	IUPAC name (1R,8R,9S,16R)-8,16-Bis(4-hydroxyphenyl)-9-[(1R,8S,9R,16R)-4,6,12-trihydroxy-8,16-bis(4-hydroxyphenyl)-15-oxatetracyclo[8.6.1.02,7.014,17]heptadeca-2(7),3,5,10(17),11,13-hexaen-9-yl]-15-oxatetracyclo[8.6.1.02,7.014,17]heptadeca-2(7),3,5,10(17),11,13-hexaene-4,6,12-triol
Identifiers
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL504634;
ChemSpider	553431;
PubChem CID	637848;
	show InChI
	show SMILES
Properties
Chemical formula	C56H42O12
Molar mass	906.940 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Hopeahainol A is a polyphenol acetylcholinesterase inhibitor with the molecular formula C₅₆H₄₂O₁₂.^[2]^[3]^[1]^[4] Hopeahainol A has been isolated from the tree Hopea hainanensis.^[4] Hopeahainol A may be used for the treatment of Alzheimer's disease.^[5]

References[]

^ Jump up to: ^a ^b "Hopeaphenol A". Pubchem.ncbi.NLM.nih.gov.
^ Rosenberry, Terrone L.; Martin, Patricia K.; Nix, A. Jeremy; Wildman, Scott A.; Cheung, Jonah; Snyder, Scott A.; Tan, Ren Xiang (November 2016). "Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence". Chemico-Biological Interactions. 259 (Pt B): 78–84. doi:10.1016/j.cbi.2016.05.032. PMC 5136322. PMID 27297626.
^ Wiart, Christophe (11 May 2012). Medicinal Plants of China, Korea, and Japan: Bioresources for Tomorrow's Drugs and Cosmetics. CRC Press. p. 229. ISBN 978-1-4398-9912-0.
^ Jump up to: ^a ^b Ge, Hui Ming; Zhu, Chun Hua; Shi, Da Hua; Zhang, Li Dong; Xie, Dai Qian; Yang, Jie; Ng, Seik Weng; Tan, Ren Xiang (January 2008). "Hopeahainol A: An Acetylcholinesterase Inhibitor from Hopea hainanensis". Chemistry - A European Journal. 14 (1): 376–381. doi:10.1002/chem.200700960. PMID 17943703.
^ Zografos, Alexandros L. (18 April 2016). From Biosynthesis to Total Synthesis: Strategies and Tactics for Natural Products. John Wiley & Sons. p. 370. ISBN 978-1-118-75173-2.

Nicolaou, K. C.; Kang, Qiang; Wu, T. Robert; Lim, Chek Shik; Chen, David Y.-K. (2 June 2010). "Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A". Journal of the American Chemical Society. 132 (21): 7540–7548. doi:10.1021/ja102623j. PMID 20462209.
Chang, Raymond Chuen-Chung (16 December 2011). Advanced Understanding of Neurodegenerative Diseases. BoD – Books on Demand. p. 170. ISBN 978-953-307-529-7.

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