Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene .[5] [6] [7]
The protein encoded by this gene is primarily found in the nucleolus , where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.
The encoded protein contains several KH domains , which are important in RNA binding and are known to be involved in RNA synthesis and metabolism . A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.[7]
See also [ ] References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000136231 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029814 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC (Feb 1999). "A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development" . Mol Cell Biol . 19 (2): 1262–70. doi :10.1128/MCB.19.2.1262 . PMC 116055 PMID 9891060 . ^ Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM (Jul 1997). "Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein" . Oncogene . 14 (22): 2729–33. doi :10.1038/sj.onc.1201110 PMID 9178771 . ^ a b "Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3" .
Further reading [ ]
Yaniv K, Yisraeli JK (2002). "The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis". Gene . 287 (1–2): 49–54. doi :10.1016/S0378-1119(01)00866-6 . PMID 11992722 . Yisraeli JK (2005). "VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins" . Biol. Cell . 97 (1): 87–96. doi :10.1042/BC20040151 PMID 15601260 . S2CID 8767105 . Mueller-Pillasch F, Pohl B, Wilda M, et al. (2000). "Expression of the highly conserved RNA binding protein KOC in embryogenesis" . Mech. Dev . 88 (1): 95–9. doi :10.1016/S0925-4773(99)00160-4 PMID 10525192 . S2CID 17091365 . Zhang JY, Chan EK, Peng XX, et al. (2001). "Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies". Clin. Immunol . 100 (2): 149–56. doi :10.1006/clim.2001.5048 . PMID 11465943 . Monk D, Bentley L, Beechey C, et al. (2002). "Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome" . J. Med. Genet . 39 (8): 575–81. doi :10.1136/jmg.39.8.575 . PMC 1735212 PMID 12161597 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72. Bibcode :2003Sci...300..767S . doi :10.1126/science.1083423 . PMC 2882961 PMID 12690205 . Nielsen J, Adolph SK, Rajpert-De Meyts E, et al. (2003). "Nuclear transit of human zipcode-binding protein IMP1" . Biochem. J . 376 (Pt 2): 383–91. doi :10.1042/BJ20030943 . PMC 1223771 PMID 12921532 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Yantiss RK, Woda BA, Fanger GR, et al. (2005). "KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas". Am. J. Surg. Pathol . 29 (2): 188–95. doi :10.1097/01.pas.0000149688.98333.54 . PMID 15644775 . S2CID 23121446 . Liao B, Hu Y, Herrick DJ, Brewer G (2005). "The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells" . J. Biol. Chem . 280 (18): 18517–24. doi :10.1074/jbc.M500270200 PMID 15753088 . Hammer NA, Hansen TO, Byskov AG, et al. (2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer" . Reproduction . 130 (2): 203–12. doi :10.1530/rep.1.00664 PMID 16049158 . Feagins LA, Susnow N, Zhang HY, et al. (2006). "Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus". Am. J. Physiol. Gastrointest. Liver Physiol . 290 (5): G871–5. doi :10.1152/ajpgi.00383.2005 . PMID 16339295 . Vikesaa J, Hansen TV, Jønson L, et al. (2006). "RNA-binding IMPs promote cell adhesion and invadopodia formation" . EMBO J . 25 (7): 1456–68. doi :10.1038/sj.emboj.7601039 . PMC 1440323 PMID 16541107 . Jiang Z, Chu PG, Woda BA, et al. (2006). "Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study". Lancet Oncol . 7 (7): 556–64. doi :10.1016/S1470-2045(06)70732-X . PMID 16814207 . Li C, Rock KL, Woda BA, et al. (2007). "IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression" . Mod. Pathol . 20 (2): 242–7. doi :10.1038/modpathol.3800735 PMID 17192788 .
PDB gallery
2e44 : Solution structure of RNA binding domain in Insulin-like growth factor 2 mRNA binding protein 3
