Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@gene.[1][2][3]
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.[4]
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Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments". Mol. Immunol. 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID12749909.
Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region". Int. J. Hematol. 81 (1): 58–61. doi:10.1532/IJH97.04119. PMID15717690. S2CID22639228.
Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID16343622.
Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL)". Hematological Oncology. 25 (2): 90–5. doi:10.1002/hon.812. PMID17410523. S2CID19587621.
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