IL17RD

IL17RD
Identifiers
Aliases	IL17RD, HH18, IL-17RD, IL17RLM, SEF, interleukin 17 receptor D
External IDs	OMIM: 606807 MGI: 2159727 HomoloGene: 9717 GeneCards: IL17RD
Gene location (Human)
Chr.	Chromosome 3 (human)
End	57,170,306 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	27,107,286 bp
Gene ontology
Molecular function	• interleukin-17 receptor activity;
Cellular component	• cytoplasm; • integral component of membrane; • Golgi apparatus; • membrane; • Golgi membrane; • plasma membrane; • integral component of plasma membrane; • nucleoplasm;
Biological process	• MAPK cascade; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	54756
	171463
	ENSG00000144730
	ENSMUSG00000040717
	Q8NFM7
	Q8JZL1
	NM_017563; NM_001318864
	NM_027265; NM_134437
	NP_001305793; NP_060033
	NP_602319
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene. ^[5]

Function[]

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the , and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144730 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040717 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Interleukin 17 receptor D". Retrieved 2016-04-17.

Further reading[]

Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003). "Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation". J. Biol. Chem. 278 (16): 14087–91. doi:10.1074/jbc.C200606200. PMID 12604616.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144730 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040717 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interleukin 17 receptor D". Retrieved 2016-04-17.

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