Intrauterine growth restriction

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Intrauterine growth restriction
Other namesFetal growth restriction (FGR),[1][2] intrauterine growth retardation,[3][4]
Villitis of unknown etiology - very high mag.jpg
Micrograph of villitis of unknown etiology, a placental pathology associated with IUGR. H&E stain.
SpecialtyPediatrics, obstetrics Edit this on Wikidata

Intrauterine growth restriction (IUGR), or fetal growth restriction, refers to poor growth of a fetus while in the womb during pregnancy. IUGR is defined by clinical features of malnutrition and evidence of reduced growth regardless of an infant's birth weight percentile.[5] The causes of IUGR are broad and may be due to involve parental, fetal, or placental complications.[6]

At least 60% of the 4 million neonatal deaths that occur worldwide every year are associated with low birth weight (LBW), caused by intrauterine growth restriction (IUGR), preterm delivery, and genetic abnormalities,[7] demonstrating that under-nutrition is already a leading health problem at birth.

Intrauterine growth restriction can result in a baby being small for gestational age (SGA), which is most commonly defined as a weight below the 10th percentile for the gestational age.[8] At the end of pregnancy, it can result in a low birth weight.

Types[]

There are two major categories of IUGR: pseudo IUGR and true IUGR[citation needed]

With pseudo IUGR, the fetus has a birth weight below the tenth percentile for the corresponding gestational age but has a normal ponderal index, subcutaneous fat deposition, and body proportion. Pseudo IUGR occurs due to uneventful intrauterine course and can be rectified by proper postnatal care and nutrition. Such babies are also called small for gestational age.[citation needed]

True IUGR occurs due to pathological conditions which may be either fetal or maternal in origin. In addition to low body weight they have abnormal ponderal index, body disproportion, and low subcutaneous fat deposition. There are two types-symmetrical and asymmetrical.[9][10] Some conditions are associated with both symmetrical and asymmetrical growth restriction.

Asymmetrical[]

Asymmetrical IUGR accounts for 70-80% of all IUGR cases.[11] In asymmetrical IUGR, there is decreased oxygen or nutrient supply to the fetus during the third trimester of pregnancy due to placental insufficiency.[12] This type of IUGR is sometimes called "head sparing" because brain growth is typically less affected, resulting in a relatively normal head circumference in these children.[13] Because of decreased oxygen supply to the fetus, blood is diverted to the vital organs, such as the brain and heart. As a result, blood flow to other organs - including liver, muscle, and fat - is decreased. This causes abdominal circumference in these children to be decreased. A lack of subcutaneous fat leads to a thin and small body out of proportion with the liver. Normally at birth the brain of the fetus is 3 times the weight of its liver. In IUGR, it becomes 5-6 times. In these cases, the embryo/fetus has grown normally for the first two trimesters but encounters difficulties in the third, sometimes secondary to complications such as pre-eclampsia. Other symptoms than the disproportion include dry, peeling skin and an overly-thin umbilical cord. The baby is at increased risk of hypoxia and hypoglycemia. This type of IUGR is most commonly caused by extrinsic factors that affect the fetus at later gestational ages. Specific causes include:[citation needed]

Symmetrical[]

Symmetrical IUGR is commonly known as global growth restriction, and indicates that the fetus has developed slowly throughout the duration of the pregnancy and was thus affected from a very early stage. The head circumference of such a newborn is in proportion to the rest of the body. Since most neurons are developed by the 18th week of gestation, the fetus with symmetrical IUGR is more likely to have permanent neurological sequelae. Common causes include:[citation needed]

Causes[]

IUGR is caused by a variety of factors; these can be fetal, parental, placental or genetic factors.[11]

Gestational Parental[]

Uteroplacental[]

Fetal[]

Genetic[]

  • Placental genes
  • Maternal genes: Endothelin-1 over-expression, Leptin under-expression
  • Fetal genes

Pathophysiology[]

If the cause of IUGR is extrinsic to the fetus (parental or uteroplacental), transfer of oxygen and nutrients to the fetus is decreased. This causes a reduction in the fetus’ stores of glycogen and lipids. This often leads to hypoglycemia at birth. Polycythemia can occur secondary to increased erythropoietin production caused by the chronic hypoxemia. Hypothermia, thrombocytopenia, leukopenia, hypocalcemia, and bleeding in the lungs are often results of IUGR.[16]

Infants with IUGR are at increased risk of perinatal asphyxia due to chronic hypoxia, usually associated with placental insufficiency, placental abruption, or a umbilical cord accident.[11] This chronic hypoxia also places IUGR infants at elevated risk of persistent pulmonary hypertension of the newborn, which can impair an infant's blood oxygenation and transition to postnatal circulation.[17]

If the cause of IUGR is intrinsic to the fetus, growth is restricted due to genetic factors or as a sequela of infection. IUGR is associated with a wide range of short- and long-term neurodevelopmental disorders.[citation needed]

Cerebral changes[]

White matter effects – In postpartum studies of infants, it was shown that there was a decrease of the fractal dimension of the white matter in IUGR infants at one year corrected age. This was compared to at term and preterm infants at one year adjusted corrected age.[citation needed]

Grey matter effects – Grey matter was also shown to be decreased in infants with IUGR at one year corrected age.[18]

Neural circuitry[]

Children with IUGR are often found to exhibit brain reorganization including neural circuitry.[19] Reorganization has been linked to learning and memory differences between children born at term and those born with IUGR.[20]

Studies have shown that children born with IUGR had lower IQ. They also exhibit other deficits that point to [frontal lobe] dysfunction.[citation needed]

IUGR infants with brain-sparing show accelerated maturation of the hippocampus which is responsible for memory.[21] This accelerated maturation can often lead to uncharacteristic development that may compromise other networks and lead to memory and learning deficiencies.[citation needed]

Management[]

Gestational parents whose fetus is diagnosed with intrauterine growth restriction can be managed with several monitoring and delivery methods. It is currently recommended that any fetus that has growth restriction and additional structural abnormalities should be evaluated with genetic testing.[6] In addition to evaluating the fetal growth velocity, the fetus should primarily be monitored by ultrasonography every 3–4 weeks.[6] An additional monitoring technique is an Doppler velocimetry. Doppler velocimetry is useful in monitoring blood flow through the uterine and umbilical arteries, and may indicate signs of uteroplacental insufficiency.[22] This method may also detect blood vessels, specifically the ductus venosus and middle cerebral arteries, which are not developing properly or may not adapt well after birth.[23] Monitoring via Doppler velocimetry has been shown to decrease the risk of morbidity and mortality before and after parturition among IUGR patients.[24] Standard fetal surveillance via nonstress tests and/or biophysical profile scoring is also recommended.[22][6] Bed rest has not been found to improve outcomes and is not typically recommended.[25] There is currently a lack of evidence supporting any dietary or supplemental changes that may prevent the development of IUGR.[6]

The optimal timing of delivery for a fetus with IUGR is unknown. However, the timing of delivery is currently based on the cause of IUGR[6] and parameters collected from the umbilical artery doppler. Some of these include: pulsatility index, resistance index, and end-diastolic velocities, which are measurements of the fetal circulation.[24] Fetuses with an anticipated delivery before 34 weeks gestation are recommended to receive corticosteroids to facilitate fetal maturation.[6][26] Anticipated births before 32 weeks should receive magnesium sulfate to protect development of the fetal brain.[27]

Outcomes[]

Postnatal Complications[]

After correcting for several factors such as low gestational parental weight, it is estimated that only around 3% of pregnancies are affected by true IUGR. 20% of stillborn infants exhibit IUGR. Perinatal mortality rates are 4-8 times higher for infants with IUGR, and morbidity is present in 50% of surviving infants.[28] Common causes of mortality in fetuses/infants with IUGR include: severe placental insufficiency and chronic hypoxia, congenital malformations, congenital infections, placental abruption, cord accidents, cord prolapse, placental infarcts, and severe perinatal depression.[5]

IUGR is more common in preterm infants than in full term (37–40 weeks gestation) infants, and its frequency decreases with increasing gestational age. Relative to premature infants who do not exhibit IUGR, premature infants with IUGR are more likely to have adverse neonatal outcomes, including respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis. This association with prematurity suggests utility of screening for IUGR as a potential risk factor for preterm labor.[29]

Feeding intolerance, hypothermia, hypoglycemia, and hyperglycemia are all common in infants in the postnatal period, indicating the need to closely manage these patients' temperature and nutrition.[30] Furthermore, rapid metabolic and physiologic changes in the first few days after birth can yield susceptibility to hypocalcemia, polycythemia, immunologic compromise, and renal dysfunction.[31][32]

Long-term Consequences[]

According to the theory of thrifty phenotype, intrauterine growth restriction triggers epigenetic responses in the fetus that are otherwise activated in times of chronic food shortage. If the offspring actually develops in an environment where food is readily accessible, it may be more prone to metabolic disorders, such as obesity and type II diabetes.[33]

Animals[]

In sheep, intrauterine growth restriction can be caused by heat stress in early to mid pregnancy. The effect is attributed to reduced placental development causing reduced fetal growth.[34][35][36] Hormonal effects appear implicated in the reduced placental development.[36] Although early reduction of placental development is not accompanied by concurrent reduction of fetal growth;[34] it tends to limit fetal growth later in gestation. Normally, ovine placental mass increases until about day 70 of gestation,[37] but high demand on the placenta for fetal growth occurs later. (For example, research results suggest that a normal average singleton Suffolk x Targhee sheep fetus has a mass of about 0.15 kg at day 70, and growth rates of about 31 g/day at day 80, 129 g/day at day 120 and 199 g/day at day 140 of gestation, reaching a mass of about 6.21 kg at day 140, a few days before parturition.[38])

In adolescent ewes (i.e. ewe hoggets), overfeeding during pregnancy can also cause intrauterine growth restriction, by altering nutrient partitioning between dam and conceptus.[39][40] Fetal growth restriction in adolescent ewes overnourished during early to mid pregnancy is not avoided by switching to lower nutrient intake after day 90 of gestation; whereas such switching at day 50 does result in greater placental growth and enhanced pregnancy outcome.[40] Practical implications include the importance of estimating a threshold for "overnutrition" in management of pregnant ewe hoggets. In a study of Romney and Coopworth ewe hoggets bred to Perendale rams, feeding to approximate a conceptus-free live mass gain of 0.15 kg/day (i.e. in addition to conceptus mass), commencing 13 days after the midpoint of a synchronized breeding period, yielded no reduction in lamb birth mass, where compared with feeding treatments yielding conceptus-free live mass gains of about 0 and 0.075 kg/day.[41] In both of the above models of IUGR in sheep, the absolute magnitude of uterine blood flow is reduced.[40] Evidence of substantial reduction of placental glucose transport capacity has been observed in pregnant ewes that had been heat-stressed during placental development.[42][43]

See also[]

References[]

  1. ^ "UpToDate".
  2. ^ "Intrauterine Growth Restriction. IUGR information".
  3. ^ Vandenbosche, Robert C.; Kirchner, Jeffrey T. (15 October 1998). "Intrauterine Growth Retardation". American Family Physician. 56 (6): 1384–1390. PMID 9803202. Retrieved 20 February 2016. Intrauterine growth retardation (IUGR), which is defined as less than 10 percent of predicted fetal weight for gestational age, may result in significant fetal morbidity and mortality if not properly diagnosed. The condition is most commonly caused by inadequate maternal-fetal circulation, with a resultant decrease in fetal growth.
  4. ^ White, Cynthia D. (16 November 2014). "Intrauterine growth restriction". MedlinePlus Medical Encyclopedia. Retrieved 21 February 2016. Alternative Names: Intrauterine growth retardation; IUGR
  5. ^ Jump up to: a b "Intrauterine Growth Restriction: Postnatal Monitoring and Outcomes". Pediatric Clinics of North America. 66 (2): 403–423. 2019-04-01. doi:10.1016/j.pcl.2018.12.009. ISSN 0031-3955.
  6. ^ Jump up to: a b c d e f g "Fetal Growth Restriction: ACOG Practice Bulletin, Number 227". Obstetrics & Gynecology. 137 (2): e16–e28. February 2021. doi:10.1097/AOG.0000000000004251. ISSN 0029-7844.
  7. ^ Lawn JE, Cousens S, Zupan J (2005). "4 million neonatal deaths: when? Where? Why?". The Lancet. 365 (9462): 891–900. doi:10.1016/s0140-6736(05)71048-5. PMID 15752534. S2CID 20891663.
  8. ^ Small for gestational age (SGA) at MedlinePlus. Update Date: 8/4/2009. Updated by: Linda J. Vorvick. Also reviewed by David Zieve.
  9. ^ "Intrauterine Growth Restriction". Archived from the original on 2007-06-09. Retrieved 2007-11-28.
  10. ^ Hunter, Stephen K.; Kennedy, Colleen M.; Peleg, David (August 1998). "Intrauterine Growth Restriction: Identification and Management - August 1998 - American Academy of Family Physicians". American Family Physician. 58 (2): 453–60, 466–7. PMID 9713399. Retrieved 2007-11-28.
  11. ^ Jump up to: a b c Sharma, Deepak; Shastri, Sweta; Sharma, Pradeep (2016). "Intrauterine Growth Restriction: Antenatal and Postnatal Aspects". Clinical Medicine Insights. Pediatrics. 10: 67–83. doi:10.4137/CMPed.S40070. ISSN 1179-5565. PMC 4946587. PMID 27441006. Cite error: The named reference ":2" was defined multiple times with different content (see the help page).
  12. ^ Wollmann, null (1998). "Intrauterine growth restriction: definition and etiology". Hormone Research. 49 (# Suppl 2): 1–6. ISSN 1423-0046. PMID 9716819.
  13. ^ Sharma, Deepak; Shastri, Sweta; Farahbakhsh, Nazanin; Sharma, Pradeep (December 2016). "Intrauterine growth restriction - part 1". The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 29 (24): 3977–3987. doi:10.3109/14767058.2016.1152249. ISSN 1476-4954. PMID 26856409.
  14. ^ Saccone G, Berghella V, Sarno L, Maruotti GM, Cetin I, Greco L, Khashan AS, McCarthy F, Martinelli D, Fortunato F, Martinelli P (October 9, 2015). "Celiac disease and obstetric complications: a systematic review and meta-analysis". Am J Obstet Gynecol. 214 (2): 225–34. doi:10.1016/j.ajog.2015.09.080. PMID 26432464.
  15. ^ Tong, Zhao; Xiaowen, Zhang; Baomin, Chen; Aihua, Liu; Yingying, Zhou; Weiping, Teng; Zhongyan, Shan (2016-05-01). "The Effect of Subclinical Maternal Thyroid Dysfunction and Autoimmunity on Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis". Medicine. 95 (19): e3677. doi:10.1097/MD.0000000000003677. ISSN 1536-5964. PMC 4902545. PMID 27175703.
  16. ^ "Intrauterine Growth Restriction: Postnatal Monitoring and Outcomes". Pediatric Clinics of North America. 66 (2): 403–423. 2019-04-01. doi:10.1016/j.pcl.2018.12.009. ISSN 0031-3955.
  17. ^ Steurer, Martina A.; Jelliffe-Pawlowski, Laura L.; Baer, Rebecca J.; Partridge, J. Colin; Rogers, Elizabeth E.; Keller, Roberta L. (2017-01-01). "Persistent Pulmonary Hypertension of the Newborn in Late Preterm and Term Infants in California". Pediatrics. 139 (1). doi:10.1542/peds.2016-1165. ISSN 0031-4005. PMID 27940508.
  18. ^ Keunen, K.; Kersbergen, K. J.; Groenendaal, F.; Isgum, I.; de Vries, L. S.; Benders, M. J. N. L. (March 2012). "Brain tissue volumes in preterm infants: prematurity, perinatal risk factors and neurodevelopmental outcome: a systematic review". The Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 25 Suppl 1: 89–100. doi:10.3109/14767058.2012.664343. ISSN 1476-4954. PMID 22348253.
  19. ^ Batalle D, Eixarch E, Figueras F, Muñoz-Moreno E, Bargallo N, Illa M, Acosta-Rojas R, Amat-Roldan I, Gratacos E (2012). "Altered small-world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome". NeuroImage. 60 (2): 1352–66. doi:10.1016/j.neuroimage.2012.01.059. PMID 22281673. S2CID 1242147.
  20. ^ Geva R, Eshel R, Leitner Y, Valevski AF, Harel S (2006). "Neuropsychological Outcome of Children With Intrauterine Growth Restriction: A 9-Year Prospective Study". Pediatrics. 118 (1): 91–100. doi:10.1542/peds.2005-2343. PMID 16818553. S2CID 11394000.
  21. ^ Black LS, deRegnier RA, Long J, Georgieff MK, Nelson CA (November 2004). "Electrographic imaging of recognition memory in 34-38 week gestation intrauterine growth restricted newborns". Experimental Neurology. 190 Suppl 1: S72–83. doi:10.1016/j.expneurol.2004.05.031. PMID 15498545. S2CID 7742685.
  22. ^ Jump up to: a b Lees, C. C.; Stampalija, T.; Baschat, A. A.; Silva Costa, F.; Ferrazzi, E.; Figueras, F.; Hecher, K.; Kingdom, J.; Poon, L. C.; Salomon, L. J.; Unterscheider, J. (August 2020). "ISUOG Practice Guidelines: diagnosis and management of small‐for‐gestational‐age fetus and fetal growth restriction". Ultrasound in Obstetrics & Gynecology. 56 (2): 298–312. doi:10.1002/uog.22134. ISSN 0960-7692.
  23. ^ Lees, C. C.; Stampalija, T.; Baschat, A. A.; Silva Costa, F.; Ferrazzi, E.; Figueras, F.; Hecher, K.; Kingdom, J.; Poon, L. C.; Salomon, L. J.; Unterscheider, J. (August 2020). "ISUOG Practice Guidelines: diagnosis and management of small‐for‐gestational‐age fetus and fetal growth restriction". Ultrasound in Obstetrics & Gynecology. 56 (2): 298–312. doi:10.1002/uog.22134. ISSN 0960-7692.
  24. ^ Jump up to: a b Sharma D, Shastri S, Sharma P (2016). "Intrauterine Growth Restriction: Antenatal and Postnatal Aspects". Clinical Medicine Insights. Pediatrics. 10: 67–83. doi:10.4137/CMPed.S40070. PMC 4946587. PMID 27441006.
  25. ^ McCall, CA; Grimes, DA; Lyerly, AD (June 2013). ""Therapeutic" bed rest in pregnancy: unethical and unsupported by data". Obstetrics and Gynecology. 121 (6): 1305–8. doi:10.1097/AOG.0b013e318293f12f. PMID 23812466. S2CID 9069311.
  26. ^ "Antenatal Corticosteroid Therapy for Fetal Maturation". Obstetric Anesthesia Digest. 29 (1): 11. March 2009. doi:10.1097/01.aoa.0000344672.12959.0d. ISSN 0275-665X.
  27. ^ "Magnesium Sulphate Given Before Very-Preterm Birth to Protect Infant Brain: The Randomised Controlled PREMAG Trial". Obstetric Anesthesia Digest. 27 (4): 175–176. December 2007. doi:10.1097/01.aoa.0000302277.08830.d0. ISSN 0275-665X.
  28. ^ Carlo L. Acerini (2013). Oxford Handbook of Paediatrics. Robert J. McClure, Robert C. Tasker. ISBN 9780191015885. OCLC 1223311499.
  29. ^ Gilbert, William M.; Danielsen, Beate (2003). "Pregnancy outcomes associated with intrauterine growth restriction". American Journal of Obstetrics and Gynecology. 188 (6): 1596–1601. doi:10.1067/mob.2003.384. ISSN 0002-9378.
  30. ^ Hoe, Francis M.; Thornton, Paul S.; Wanner, Laura A.; Steinkrauss, Linda; Simmons, Rebecca A.; Stanley, Charles A. (February 2006). "Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism". The Journal of Pediatrics. 148 (2): 207–212. doi:10.1016/j.jpeds.2005.10.002.
  31. ^ Hyman, Sharon J.; Novoa, Yeray; Holzman, Ian (October 2011). "Perinatal Endocrinology: Common Endocrine Disorders in the Sick and Premature Newborn". Pediatric Clinics of North America. 58 (5): 1083–1098. doi:10.1016/j.pcl.2011.07.003.
  32. ^ Mukhopadhyay, Dhriti; Weaver, Laura; Tobin, Richard; Henderson, Stephanie; Beeram, Madhava; Newell-Rogers, M. Karen; Perger, Lena (May 2014). "Intrauterine growth restriction and prematurity influence regulatory T cell development in newborns". Journal of Pediatric Surgery. 49 (5): 727–732. doi:10.1016/j.jpedsurg.2014.02.055. ISSN 0022-3468.
  33. ^ Barker, D. J. P., ed. (1992). Fetal and infant origins of adult disease. London: British Medical Journal. ISBN 978-0-7279-0743-1.
  34. ^ Jump up to: a b Vatnick I, Ignotz G, McBride BW, Bell AW (September 1991). "Effect of heat stress on ovine placental growth in early pregnancy". Journal of Developmental Physiology. 16 (3): 163–6. PMID 1797923.
  35. ^ Bell A. W.; McBride B. W.; Slepetis R.; Early R. J.; Currie W. B. (1989). "Chronic Heat Stress and Prenatal Development in Sheep: I. Conceptus Growth and Maternal Plasma Hormones and Metabolites". Journal of Animal Science. 67 (12): 3289–3299. doi:10.2527/jas1989.67123289x. PMID 2613577. S2CID 9440955.
  36. ^ Jump up to: a b Regnault TR, Orbus RJ, Battaglia FC, Wilkening RB, Anthony RV (September 1999). "Altered arterial concentrations of placental hormones during maximal placental growth in a model of placental insufficiency". The Journal of Endocrinology. 162 (3): 433–42. doi:10.1677/joe.0.1620433. PMID 10467235.
  37. ^ Ehrhardt RA, Bell AW (December 1995). "Growth and metabolism of the ovine placenta during mid-gestation". Placenta. 16 (8): 727–41. doi:10.1016/0143-4004(95)90016-0. PMID 8710803.
  38. ^ Rattray PV, Garrett WN, East NE, Hinman N (March 1974). "Growth, development and composition of the ovine conceptus and mammary gland during pregnancy". Journal of Animal Science. 38 (3): 613–26. doi:10.2527/jas1974.383613x. PMID 4819552.
  39. ^ Wallace J. M. (2000). "Nutrient partitioning during pregnancy: adverse gestational outcome in overnourished adolescent dams". Proc. Nutr. Soc. 59 (1): 107–117. doi:10.1017/s0029665100000136. PMID 10828180.
  40. ^ Jump up to: a b c Wallace J. M.; Regnault T. R. H.; Limesand S. W.; Hay Jr.; Anthony R. V. (2005). "Investigating the causes of low birth weights in contrasting ovine paradigms". J. Physiol. 565 (Pt 1): 19–26. doi:10.1113/jphysiol.2004.082032. PMC 1464509. PMID 15774527.
  41. ^ Morris ST, Kenyon PR, West DM (2010). "Effect of hogget nutrition in pregnancy on lamb birthweight and survival to weaning". New Zealand Journal of Agricultural Research. 48 (2): 165–175. doi:10.1080/00288233.2005.9513647. ISSN 0028-8233.
  42. ^ Bell AW, Wilkening RB, Meschia G (February 1987). "Some aspects of placental function in chronically heat-stressed ewes". Journal of Developmental Physiology. 9 (1): 17–29. PMID 3559063.
  43. ^ Thureen PJ, Trembler KA, Meschia G, Makowski EL, Wilkening RB (September 1992). "Placental glucose transport in heat-induced fetal growth retardation". The American Journal of Physiology. 263 (3 Pt 2): R578–85. doi:10.1152/ajpregu.1992.263.3.R578. PMID 1415644.

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