Isothiazole
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Names | |||
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Preferred IUPAC name
1,2-Thiazole[1] | |||
Other names
isothiazole
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Identifiers | |||
3D model (JSmol)
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ChEBI | |||
ChemSpider | |||
ECHA InfoCard | 100.241.294 | ||
PubChem CID
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UNII | |||
CompTox Dashboard (EPA)
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Properties | |||
C3H3NS | |||
Molar mass | 85.12 g·mol−1 | ||
Boiling point | 114 °C (237 °F; 387 K)[3] | ||
Acidity (pKa) | -0.5 (of conjugate acid)[2] | ||
Related compounds | |||
Related compounds
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thiazole, isoxazole | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |||
what is ?) | (|||
Infobox references | |||
An isothiazole, or 1,2-thiazole, is a type of organic compound containing a five-membered aromatic ring that consists of three carbon atoms, one nitrogen atom, and one sulfur atom.[4] Isothiazole is a member of a class of compounds known as azoles. In contrast to the isomeric thiazole, the two heteroatoms are in adjacent positions.
The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.
See also[]
References[]
- ^ International Union of Pure and Applied Chemistry (2014). Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. p. 140. doi:10.1039/9781849733069. ISBN 978-0-85404-182-4.
- ^ Zoltewicz, J. A. & Deady, L. W. Quaternization of heteroaromatic compounds. Quantitative aspects. Adv. Heterocycl. Chem. 22, 71-121 (1978)
- ^ Isothiazoles, D. W. Brown and M. Sainsbury, page 513
- ^ Heterocyclic Chemistry, 3rd Edition, J.A. Joule, K. Mills, and G.F. Smith, page 394
Categories:
- Isothiazoles
- Heterocyclic compound stubs