Joseph DeRisi

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Joseph DeRisi
NationalityAmerican
Alma materStanford University, University of California, Santa Cruz
Known forViroChip, work on identifying SARS virus, gene expression in Plasmodium falciparum
Scientific career
FieldsBiology
InstitutionsUniversity of California, San Francisco Howard Hughes Medical Institute
ThesisThe Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae. (1999)
Doctoral advisorPatrick O. Brown

Joseph Lyman DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology.

Life[]

He received a B.S. in Biochemistry and Molecular Biology (1992) from the University of California, Santa Cruz, and a Ph.D. in Biochemistry (1999) from Stanford University.

Joseph DeRisi is a co-president of the Chan Zuckerberg Biohub, and Chair of the Department of Biochemistry and Biophysics at the University of California, San Francisco (UCSF) with a joint appointment at the California Institute for Quantitative Biosciences (QB3).[1][2] He is a former Howard Hughes Medical Institute (HHMI) Investigator.

DeRisi's best-known achievements are printing the first whole genome expression array,[3] performing the first broad analysis of differential gene expression in cancer cells,[4] profiling gene expression throughout the lifecycle of the malaria-causing protozoan Plasmodium falciparum,[5] his discovery of the SARS virus,[6] and pioneering virus discovery using gene hybridization array and DNA sequencing technologies.[7]

DeRisi uses microarrays extensively in his work, and has designed and built both hardware and software for microarrays. He is a proponent of open access to microarray technology,[citation needed] and maintains a website with software and protocols for microarray operations.[citation needed] He is also a proponent of open access publishing,[citation needed] and has publications in the Public Library of Science journals.[8]

DeRisi has identified putative disease-causing viruses in humans (cancer, SARS, other respiratory infections, paraneoplastic encephalitis, etc.), and animals ranging from parrots and cockatiels to honeybees and boa constrictors.[9] He and a research partner, Don Ganem, have identified a parasite, Nosema ceranae, that appears to be responsible for colony collapse among honeybees.[10] He has also de-bunked the relation of viruses to certain subsets of human cancer.[11]

Perhaps most relevant to contemporary global health, based on extensive characterization of the malaria-causing pathogen, Plasmodium falciparum, DeRisi's group has developed profoundly promising candidate drugs to cure malaria.[12]

In 2004 DeRisi was named a MacArthur fellow (the "Genius" award), in 2008 was awarded the 14th Annual Heinz Award for Technology, the Economy, and Employment, in 2013 was elected as a fellow of the California Academy of Sciences and to the Academy of the American Society of Microbiology, and in 2014 he received the John J. Carty Award for the Advancement of Science from the National Academy of Sciences.[13][14] In 2015, he was elected to the American Academy of Arts and Sciences, and in 2016 he was elected to the National Academy of Sciences and the National Academy of Medicine.[15][16]

He was involved in the development of the ViroChip, which is used to rapidly identify viruses in bodily fluids. It was used to help identify the Severe acute respiratory syndrome virus in 2003. He has also been involved in the development of an online platform called IDseq,[17] backed by the Chan Zuckerberg Initiative and Chan Zuckerberg Biohub, which is used to identify viruses from metagenomic sequencing data.[18][19]

In 2020, during the COVID-19 pandemic, DeRisi led a team that turned an empty lab space adjacent to the CZ Biohub into a CLIA-certified COVID-19 testing facility in eight days. CLIAhub became one of the nation’s leading COVID-19 testing centers, processing thousands of tests per day and becoming a model for the nation. [20][21][22][23][24]

At the same time, DeRisi became an active proponent of developing a national COVID-19 surveillance system to identify and monitor the COVID-19 virus' mutations. [25][26][23]

Awards[]

References[]

  1. ^ Kerr, Dara (September 21, 2016). "Chan Zuckerberg Initiative invests $3B to cure all diseases". cnet.com. Retrieved May 1, 2021.
  2. ^ Gerrity, Ashley (September 22, 2016). "UC Berkeley to collaborate with UCSF, Stanford in Chan Zuckerberg Biohub". dailycal.org. Retrieved May 1, 2021.
  3. ^ DeRisi, JL; Iyer, VR; Brown, PO (1997). "Exploring the metabolic and genetic control of gene expression on a genomic scale". Science. 278 (5338): 680–6. Bibcode:1997Sci...278..680D. CiteSeerX 10.1.1.335.7937. doi:10.1126/science.278.5338.680. PMID 9381177.
  4. ^ DeRisi, J; Penland, L; Brown, PO; Bittner, ML; Meltzer, PS; Ray, M; Chen, Y; Su, YA; Trent, JM (1996). "Use of a cDNA microarray to analyse gene expression patterns in human cancer". Nat Genet. 14 (4): 457–60. doi:10.1038/ng1296-457. PMID 8944026. S2CID 23091561.
  5. ^ Llinas, Manuel; Bozdech, Zbynek; Wong, Edith D.; Adai, Alex T.; Derisi, Joseph L. (2006), "Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains", Nucleic Acids Research, 34 (4): 1166–73, doi:10.1093/nar/gkj517, PMC 1380255, PMID 16493140
  6. ^ Rota, Paul A.; Oberste, M. Steven; Monroe, Stephan S.; Nix, W. Allan; Campagnoli, Ray; Icenogle, Joseph P.; Penaranda, Silvia; Bankamp, Bettina; Maher, Kaija; Bellini, William J. (2003), "Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome", Science, 300 (5624): 1394–9, Bibcode:2003Sci...300.1394R, doi:10.1126/science.1085952, PMID 12730500
  7. ^ Wang, D; Coscoy, L; Zylberberg, M; Avila, PC; Boushey, HA; Ganem, D; DeRisi, JL (2002). "Microarray-based detection and genotyping of viral pathogens". Proc Natl Acad Sci U S A. 99 (24): 15687–92. Bibcode:2002PNAS...9915687W. doi:10.1073/pnas.242579699. PMC 137777. PMID 12429852.
  8. ^ Bozdech, Zbynek; Llinás, Manuel; Pulliam, Brian Lee; Wong, Edith D.; Zhu, Jingchun; Derisi, Joseph L. (2003), "The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum", PLOS Biology, 1 (1): e5, doi:10.1371/journal.pbio.0000005, PMC 176545, PMID 12929205 open access
  9. ^ Dubey, Divyanshu; Mandel-Brehm, Caleigh (July 4, 2019). "Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis". The New England Journal of Medicine. 381 (1): 47–54. doi:10.1056/NEJMoa1816721. PMC 6800027. PMID 31269365.
  10. ^ "UCSF Sleuths Identify Suspects in Mystery of Vanishing Honeybees".
  11. ^ Allday, Erin (July 15, 2019). "Rare disease discovery: Antibodies fighting cancer go on to attack brain". sfchronicle.com. Retrieved May 1, 2021.
  12. ^ Jiménez-Díaz, María; Ebert, Daniel (December 1, 2014). "(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium". Proceedings of the National Academy of Sciences of the United States of America. 111 (50): E5455-62. Bibcode:2014PNAS..111E5455J. doi:10.1073/pnas.1414221111. PMC 4273362. PMID 25453091.
  13. ^ "California Academy of Sciences Welcomes New Fellows, Bestows Annual Awards". calacademy.org. October 4, 2013. Retrieved May 1, 2021.
  14. ^ "65 Fellows Elected into the American Academy of Microbiology". asm.org. February 16, 2021. Retrieved May 1, 2021.
  15. ^ National Academy of Sciences Members and Foreign Associates Elected, News from the National Academy of Sciences, National Academy of Sciences, May 3, 2016, archived from the original on May 6, 2016, retrieved 2016-05-14.
  16. ^ Bai, Nina (October 17, 2016). "3 UCSF Faculty Elected to the National Academy of Medicine for 2016". ucsf.edu. Retrieved May 1, 2021.
  17. ^ Kalantar, Katrina L; Carvalho, Tiago; de Bourcy, Charles F A; Dimitrov, Boris; Dingle, Greg; Egger, Rebecca; Han, Julie; Holmes, Olivia B; Juan, Yun-Fang; King, Ryan; Kislyuk, Andrey (October 2020). "IDseq—An open source cloud-based pipeline and analysis service for metagenomic pathogen detection and monitoring". GigaScience. 9 (10). doi:10.1093/gigascience/giaa111. ISSN 2047-217X. PMC 7566497. PMID 33057676.
  18. ^ "A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries". The Atlantic. 16 October 2018. Retrieved 27 November 2018.
  19. ^ Masterson, Kathleen (April 22, 2015). "4 UCSF Faculty Elected to American Academy of Arts and Sciences' 2015 Class". ucsf.edu. Retrieved May 1, 2021.
  20. ^ "A Model for the Nation: Building a COVID-19 Testing Lab in Only Eight Days". chanzuckerberg.com. October 21, 2020. Retrieved May 1, 2021.
  21. ^ Lewis, Michael (April 16, 2020). "The Covid Test Lab That Could Save America". bloomberg.com. Retrieved May 1, 2021.
  22. ^ Lewis, Michael (May 8, 2020). "Armed With Swabs, Covid Hunters Stalk Their Prey". bloomberg.com. Retrieved May 1, 2021.
  23. ^ Jump up to: a b Lewis, Michael (June 21, 2020). "The New Weapon in the Covid-19 War". bloomberg.com. Retrieved May 1, 2021.
  24. ^ Lewis, Michael (April 7, 2020). "In Berkeley, Hunting Toilet Paper and Dodging Hikers". bloomberg.com. Retrieved May 1, 2021.
  25. ^ Dunn, Lauren (January 8, 2021). "As U.K. variant spreads in U.S., scientists warn that country isn't doing enough to track Covid strains". NBCNews.com. Retrieved May 1, 2021.
  26. ^ Allday, Erin (January 23, 2021). "The inside story of how the Bay Area coronavirus variant was discovered". sfchronicle.com. Retrieved May 1, 2021.

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