KIF4A

KIF4A
Identifiers
Aliases	KIF4A, KIF4, KIF4G1, MRX100, kinesin family member 4A, XLID100
External IDs	OMIM: 300521 MGI: 108389 HomoloGene: 69022 GeneCards: KIF4A
Gene location (Human)
Chr.	X chromosome (human)
End	70,420,886 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	99,770,820 bp
RNA expression pattern
	Top expressed in
	liver; ; material anatomical entity; ; ovary; ; testicle; ; heart; ; lung; ; embryo; ; kidney; ; cerebral cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; microtubule motor activity; nucleotide binding; microtubule binding; GO:0001948 protein binding; ATP binding; plus-end-directed microtubule motor activity; ATPase activity;
Cellular component	cytosol; membrane; kinesin complex; nuclear matrix; spindle; nucleoplasm; chromosome; spindle microtubule; microtubule; cytoskeleton; nucleus; axon cytoplasm; midbody; cytoplasm; intercellular bridge;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic spindle midzone assembly; mitotic cytokinesis; organelle organization; anterograde axonal transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; microtubule-based movement; GO:0043148 mitotic spindle organization;
	Sources:Amigo / QuickGO
Orthologs
	24137
	16571
	ENSG00000090889
	ENSMUSG00000034311
	O95239
	P33174
	NM_012310
	NM_008446
	NP_036442
	NP_032472
	Wikidata
View/Edit Human	View/Edit Mouse

Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.^[1]^[2]

KIF4A Foundation is a nonprofit organization dedicated to connecting families affected by KIF4A Associated Syndrome (KAS) and accelerating research to find treatments. Visit KIF4A.org for more information.

Function[]

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.^[2]

Interactions[]

KIF4A has been shown to interact with HMG20B^[7] and DNMT3B.^[8]

References[]

^ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–2. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.
^ ^a ^b "Entrez Gene: KIF4A kinesin family member 4A".
^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090889 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034311 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee YM, Kim W (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Further reading[]

Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N (Oct 1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally". The Journal of Cell Biology. 127 (1): 187–201. doi:10.1083/jcb.127.1.187. PMC 2120182. PMID 7929562.
Yan RT, Wang SZ (Apr 1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene. 189 (2): 263–7. doi:10.1016/S0378-1119(96)00860-8. PMID 9168136.
Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, Goff SP, Morse HC (Dec 1999). "Cellular motor protein KIF-4 associates with retroviral Gag". Journal of Virology. 73 (12): 10508–13. doi:10.1128/JVI.73.12.10508-10513.1999. PMC 113106. PMID 10559369.
Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, Morse HC, Kim W (Sep 2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (1–2): 219–24. doi:10.1016/s0167-4781(00)00151-2. PMID 10978527.
Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W (Dec 2001). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis". The Biochemical Journal. 360 (Pt 3): 549–56. doi:10.1042/0264-6021:3600549. PMC 1222256. PMID 11736643.
Lee YM, Kim W (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Lee YM, Kim W (Feb 2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells". Experimental & Molecular Medicine. 36 (1): 93–7. doi:10.1038/emm.2004.13. PMID 15031677.
Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K (Aug 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal. 23 (16): 3237–48. doi:10.1038/sj.emboj.7600347. PMC 514520. PMID 15297875.
Mazumdar M, Sundareshan S, Misteli T (Aug 2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation". The Journal of Cell Biology. 166 (5): 613–20. doi:10.1083/jcb.200401142. PMC 2172419. PMID 15326200.
Zhu C, Jiang W (Jan 2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (2): 343–8. Bibcode:2005PNAS..102..343Z. doi:10.1073/pnas.0408438102. PMC 544298. PMID 15625105.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[pmid10773663-1] Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–2. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.

[entrez-2] "Entrez Gene: KIF4A kinesin family member 4A".

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000090889 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000034311 - Ensembl, May 2017

[5] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12809554-7] Lee YM, Kim W (Sep 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.

[pmid15148359-8] Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

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