Kalafungin

Kalafungin
Clinical data
Other names	U-19718
ATC code	None;
Identifiers
	IUPAC name (3aR,5R,11bR)-7-Hydroxy-5-methyl-3,3a,5,11b-tetrahydro-2H-benzo[g]furo[3,2-c]isochromene-2,6,11-trione;
CAS Number	11048-15-0;
PubChem CID	283138;
ChemSpider	391931;
UNII	7HR91T5TGW;
KEGG	D04648;
ChEMBL	ChEMBL1988648;
CompTox Dashboard (EPA)	DTXSID40864305 ;
Chemical and physical data
Formula	C16H12O6
Molar mass	300.266 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C2=C([C@@H]3[C@H](O1)CC(=O)O3)C(=O)c4cccc(c4C2=O)O;
	InChI InChI=1S/C16H12O6/c1-6-11-13(16-9(21-6)5-10(18)22-16)14(19)7-3-2-4-8(17)12(7)15(11)20/h2-4,6,9,16-17H,5H2,1H3/t6-,9-,16+/m1/s1; Key:XUWPJKDMEZSVTP-LTYMHZPRSA-N;

Kalafungin is a substance discovered in the 1960s and found to act as a broad-spectrum antibiotic in vitro. It was isolated from a strain of the bacterium Streptomyces tanashiensis.^[1]^[2]

It is not known to be marketed anywhere in the world.^[3]

References[]

^ Bergy ME (July 1968). "Kalafungin, a new broad spectrum antibiotic. Isolation and characterization". The Journal of Antibiotics. 21 (7): 454–7. doi:10.7164/antibiotics.21.454. PMID 4303501.
^ Johnson LE, Dietz A (December 1968). "Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala". Applied Microbiology. 16 (12): 1815–21. doi:10.1128/AEM.16.12.1815-1821.1968. PMC 547777. PMID 5726156.
^ "Kalafungin search results". Drugs.com. Retrieved 2021-03-31.

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[1] Bergy ME (July 1968). "Kalafungin, a new broad spectrum antibiotic. Isolation and characterization". The Journal of Antibiotics. 21 (7): 454–7. doi:10.7164/antibiotics.21.454. PMID 4303501.

[2] Johnson LE, Dietz A (December 1968). "Kalafungin, a new antibiotic produced by Streptomyces tanashiensis strain Kala". Applied Microbiology. 16 (12): 1815–21. doi:10.1128/AEM.16.12.1815-1821.1968. PMC 547777. PMID 5726156.

[3] "Kalafungin search results". Drugs.com. Retrieved 2021-03-31.

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