Karyorrhexis

Morphological characteristics of pyknosis and other forms of nuclear destruction

Karyorrhexis (from Greek κάρυον karyon, "kernel, seed or nucleus", and ῥῆξις rhexis, "bursting") is the destructive fragmentation of the nucleus of a dying cell^[1] whereby its chromatin is distributed irregularly throughout the cytoplasm.^[2] It is usually preceded by pyknosis and can occur as a result of either programmed cell death (apoptosis), cellular senescence, or necrosis.

In apoptosis, the cleavage of DNA is done by Ca²⁺ and Mg²⁺ -dependent endonucleases.

References[]

^ Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. Bibcode:1999Natur.401..127Z. doi:10.1038/43591. PMID 10490018. S2CID 36673000.
^ Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. Retrieved 11 November 2017.

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[zamzami-1] Zamzami N, Kroemer G (1999). "Apoptosis: Condensed matter in cell death". Nature. 401 (127): 127–8. Bibcode:1999Natur.401..127Z. doi:10.1038/43591. PMID 10490018. S2CID 36673000.

[2] Advances in Mutagenesis Research. Springer Science & Business Media. 2012. p. 11. ISBN 9783642781933. Retrieved 11 November 2017.

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Karyorrhexis

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