Katherine A. Fitzgerald

From Wikipedia, the free encyclopedia
Katherine Fitzgerald
Born
Katherine A. Fitzgerald

Ireland
CitizenshipUnited States of America
Alma materUniversity College Cork,
Trinity College Dublin
Scientific career
ThesisSignal transduction processes regulating CD44 expression and CD44-mediated changes in pro-inflammatory gene expression (1999)

Katherine A. Fitzgerald is an Irish-born American molecular biologist and virologist.[1] She is a professor of medicine currently working in the Division of Infectious Disease at the University of Massachusetts Medical School. She is also the director of the Program in Innate Immunity.[2]

Education[]

Fitzgerald received her B.Sc. degree in Biochemistry in 1995 from University College Cork.[1] She received her Ph.D. in 1999 from Trinity College Dublin,[3] studying with Luke O'Neill.[1] Following her Ph.D., she was postdoc at Trinity College Dublin until 2004 when she moved to the University of Massachusetts Medical School.[4]

Research[]

Fitzgerald is known for her research in the field of innate immunity and the biology behind inflammatory responses in diseases.[5] She conducts research on many aspects of innate immunity such as the molecular basis of pathogen recognition,[6] the innate immunity to malaria,[7] and the impact with diseases such as lupus or rheumatoid arthritis.[8] In 2021, Fitzgerald published results on an antiviral option to block replication in SARS-CoV-2, the viral agent responsible for COVID-19.[9]

Selected publications[]

  • Fitzgerald, Katherine A.; Palsson-McDermott, Eva M.; Bowie, Andrew G.; Jefferies, Caroline A.; Mansell, Ashley S.; Brady, Gareth; Brint, Elizabeth; Dunne, Aisling; Gray, Pearl; Harte, Mary T.; McMurray, Diane (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. ISSN 0028-0836.
  • Fitzgerald, Katherine A.; Rowe, Daniel C.; Barnes, Betsy J.; Caffrey, Daniel R.; Visintin, Alberto; Latz, Eicke; Monks, Brian; Pitha, Paula M.; Golenbock, Douglas T. (2003-10-06). "LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF". Journal of Experimental Medicine. 198 (7): 1043–1055. doi:10.1084/jem.20031023. ISSN 1540-9538. PMC 2194210. PMID 14517278.
  • Hornung, Veit; Ablasser, Andrea; Charrel-Dennis, Marie; Bauernfeind, Franz; Horvath, Gabor; Caffrey, Daniel. R.; Latz, Eicke; Fitzgerald, Katherine A. (2009). "AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC". Nature. 458 (7237): 514–518. doi:10.1038/nature07725. ISSN 0028-0836. PMC 2726264. PMID 19158675.

Awards[]

In 2011, Fitzgerald was a finalist for the Vilcek Prize for Creative Promise in Biomedical Science.[10] In 2015, she was awarded the Science Foundation Ireland (SFI) St. Patrick’s Day Science Medal, and she is the first woman to win the award.[11] She was awarded the Thomson Reuters Highly Cited Researcher in 2014 and 2015, for being in the top 1% of authors cited in her field.[12] In 2020, she was admitted into the Royal Irish Academy, one of Ireland's most prestigious academic bodies,[13][14] and was elected to the American Academy of Microbiology.[15] In 2021 she was elected to the United States' National Academy of Sciences[16] and the National Academy of Medicine.[17]

References[]

  1. ^ a b c "Dr. Katherine A. Fitzgerald, Ph.D." The Milstein Awards. 2014-06-21. Retrieved 2019-10-22.
  2. ^ "Program in Innate Immunity". Retrieved September 28, 2020.
  3. ^ Fitzgerald, Katherine (1999). Signal transduction processes regulating CD44 expression and CD44-mediated changes in pro-inflammatory gene expression (Thesis).
  4. ^ "Principal Investigator". UMass Chan Medical School. 2016-08-23. Retrieved 2021-10-02.
  5. ^ "Katherine Fitzgerald focuses on novel discoveries in innate immunity". University of Massachusetts Medical School. 2016-08-02. Retrieved 2019-10-22.
  6. ^ Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A. (2011). "Recognition of herpesviruses by the innate immune system". Nature Reviews Immunology. 11 (2): 143–154. doi:10.1038/nri2937. ISSN 1474-1733. PMC 3686362. PMID 21267015.
  7. ^ Gazzinelli, Ricardo T.; Kalantari, Parisa; Fitzgerald, Katherine A.; Golenbock, Douglas T. (2014). "Innate sensing of malaria parasites". Nature Reviews Immunology. 14 (11): 744–757. doi:10.1038/nri3742. ISSN 1474-1733.
  8. ^ "Richter, Fitzgerald named to newly endowed chairs". UMass Medical School. 2015.
  9. ^ Humphries, Fiachra; Shmuel-Galia, Liraz; Jiang, Zhaozhao; Wilson, Ruth; Landis, Philip; Ng, Sze-Ling; Parsi, Krishna Mohan; Maehr, Rene; Cruz, John; Morales, Angel; Ramanjulu, Joshi M. (2021-05-18). "A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection". Science Immunology. 6 (59): eabi9002. doi:10.1126/sciimmunol.abi9002. PMC 8158975. PMID 34010139.
  10. ^ "The Vilcek Foundation -". www.vilcek.org. Retrieved 2015-11-12.
  11. ^ O’Connell, Claire (2015-03-16). "Irish researcher Katherine Fitzgerald receives St Patrick's Day Science Medal - Discovery | siliconrepublic.com - Ireland's Technology News Service". Silicon Republic. Retrieved 2019-10-22.
  12. ^ Megan, Bard (February 4, 2016). "Fitzgerald named again in Thomson Reuters Report on most influential scientific minds".
  13. ^ "Royal Irish Academy - Katherine Fitzgerald".
  14. ^ Spencer, Susan (2020). "UMMS immunologist Katherine Fitzgerald admitted to Royal Irish Academy".
  15. ^ "Katherine Fitzgerald and Sanjay Ram elected to American Academy of Microbiology". UMass Chan Medical School. 2020-02-24. Retrieved 2021-10-02.
  16. ^ "News from the National Academy of Sciences". 26 April 2021. Retrieved 2 July 2021. Newly elected members and their affiliations at the time of election are: ... Fitzgerald, Katherine A.; professor, department of medicine, and Worcester Foundation for Biomedical Research Chair, University of Massachusetts Medical School, Worcester
  17. ^ "National Academy of Medicine Elects 100 New Members". National Academy of Medicine. October 18, 2021. Retrieved October 18, 2021.

External links[]

Retrieved from ""