Kendomycin
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Names | |
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IUPAC name
(1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one
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Systematic IUPAC name
(1R,9S,10S,12S,14E,16S,19R,20R,21S,22R)-3,9,21-Trihydroxy-5,10,12,14,16,20,22-heptamethyl-23,24-dioxatetracyclo[17.3.1.16,9.02,7]tetracosa-2,5,7,14-tetraen-4-one | |
Other names
(-)-TAN 2162
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
MeSH | C485395 |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C29H42O6 | |
Molar mass | 486.64 g/mol |
Appearance | Yellow powder |
Solubility in DMSO, methanol | Soluble |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Toxic |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
Kendomycin is an anticancer macrolide first isolated from Streptomyces violaceoruber.[2] It has potent activity as an endothelin receptor antagonist and anti-osteoporosis agent.[3] It also has strong cytotoxicity against various tumor cell lines.[2]
Total synthesis[]
Because of its potent biological activities, kendomycin has attracted interest as a target of total synthesis. The first total synthesis of kendomycin was accomplished by Lee and Yuan in 2004.[4] The total number of syntheses stands at 6.[5][6][7][8][9]
References[]
- ^ Kendomycin Archived 2008-05-16 at the Wayback Machine at Alexis-Biochemicals
- ^ a b H B Bode; A Zeeck (2000). "Structure and biosynthesis of kendomycin, a carbocyclic ansa-compound from Streptomyces". J. Chem. Soc. Perkin Trans. 1. 323 (3): 323–328. doi:10.1039/a908387a.
- ^ Burke Research Group Archived 2006-08-29 at the Wayback Machine University of Wisconsin
- ^ Yu Yuan; Hongbin Men; Chulbom Lee (2004). "Total Synthesis of Kendomycin: A Macro−C−Glycosidation Approach". J. Am. Chem. Soc. 126 (45): 14720–14721. doi:10.1021/ja0447154. PMC 1785127. PMID 15535687.
- ^ A B Smith III; E F Mesaros; E Meyer (2006). "Evolution of a Total Synthesis of (−)-Kendomycin Exploiting a Petasis−Ferrier Rearrangement/Ring-Closing Olefin Metathesis Strategy". J. Am. Chem. Soc. 128 (15): 5292–9. doi:10.1021/ja060369+. PMID 16608366.
- ^ J T Lowe; J S Panek (2008). "Total Synthesis of (−)-Kendomycin". Org. Lett. 10 (17): 3813–6. doi:10.1021/ol801499s. PMID 18698784.
- ^ K B Bahnck; S D Rychnovsky (2008). "Formal Synthesis of (−)-Kendomycin Featuring a Prins-Cyclization to Construct the Macrocycle". J. Am. Chem. Soc. 130 (13): 13177–81. doi:10.1021/ja805187p. PMC 2697922. PMID 18767844.
- ^ Magauer, Thomas; Martin, Harry J.; Mulzer, Johann (2009). "Total Synthesis of the Antibiotic Kendomycin by Macrocyclization using Photo-Fries Rearrangement and Ring-Closing Metathesis". Angewandte Chemie International Edition. 48 (33): 6032–6. doi:10.1002/anie.200900522. PMID 19350596.
- ^ Martin, Harry J.; Magauer, Thomas; Mulzer, Johann (2010). "In Pursuit of a Competitive Target: Total Synthesis of the Antibiotic Kendomycin". Angewandte Chemie International Edition. 49 (33): 5614–26. doi:10.1002/anie.201000227. PMID 20818753.
Categories:
- Macrolides
- Antibiotics
- Quinone methides
- Total synthesis