Kenneth Poss

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Ken Poss

Ph.D.
Kenneth Poss, 2018
Poss in 2018
Born
Green Bay, Wisconsin, U.S.
Alma materCarleton College Massachusetts Institute of Technology
Scientific career
Doctoral advisorSusumu Tonegawa
Other academic advisorsMark Keating
Websitesites.duke.edu/posslab

Kenneth D. Poss (born 1971 in Green Bay, Wisconsin) is an American biologist and currently James B. Duke Professor of Cell Biology and director of the Regeneration Next Initiative at the Duke University School of Medicine (Durham, North Carolina).

Career[]

Poss received a B.A. in Biology from Carleton College (Minnesota) in 1992, and a Ph.D. in Biology in 1998 from Massachusetts Institute of Technology working with Susumu Tonegawa. Poss did postdoctoral research with Mark Keating, first at University of Utah and then at Harvard Medical School. Poss became faculty in the Department of Cell Biology at Duke University in 2003.[1]

Research[]

Poss uses zebrafish to understand how and why tissue regeneration occurs. As a postdoc, he led the first positional cloning of a gene required for regeneration of amputated fins,[2] and he established zebrafish as a model for innate heart regeneration.[3]  With the latter discovery, it became clear that heart regeneration occurs and is efficient in some vertebrates, and that it could be dissected using molecular genetics in a tractable model system. Since then, he and his postdocs, students, and staff have innovated many tools to interrogate tissue regeneration.  Poss reported that heart muscle cells, not stem cells, are activated by injury to divide and directly replace lost cardiac tissue.[4]  His lab has a history of research findings on the outer layer of the heart called the epicardium, beginning with discovery of its dynamism upon injury,[5] to its fate-mapping,[6] to its roles in releasing pro-regenerative factors, and to studies describing its own regenerative capacity.[7][8] His group applied Brainbow-based technology to demonstrate that particularly high proliferative activity by a small number of muscle cells, known as clonal dominance, creates the structure of the adult heart.[9]  His lab also identified a key factor important for the process by which zebrafish regenerate spinal cord tissue to reverse a paralyzing injury.[10] Recently, he introduced the concept of tissue regeneration enhancer elements (TREEs), sequences that regulate regeneration programs and can be engineered to enhance tissue regeneration.[11][12]

Awards[]

Poss was a Helen Hay Whitney Foundation Postdoctoral Fellow, a Pew Scholar, and a Howard Hughes Medical Institute Early Career Scientist. He received the Established Investigator and Merit Awards from the American Heart Association, the Ruth and A. Morris Williams Faculty Research Prize from Duke University, and the Distinguished Achievement Award from Carleton College. Poss was named a Fellow of the American Association for the Advancement of Science.

Selected studies, videos and interviews[]

References[]

  1. ^ a b Mercader, Nadia; Serras, Florenci (2018). "Can broken hearts be mended? Ken Poss, a pioneer on heart regeneration research". The International Journal of Developmental Biology. 62 (6–7–8): 383–386. doi:10.1387/ijdb.180088fs. ISSN 0214-6282. PMID 29938751.
  2. ^ Poss, Kenneth D.; Shen, Jiaxiang; Nechiporuk, Alex; McMahon, Gerald; Thisse, Bernard; Thisse, Christine; Keating, Mark T. (June 2000). "Roles for Fgf Signaling during Zebrafish Fin Regeneration". Developmental Biology. 222 (2): 347–358. doi:10.1006/dbio.2000.9722. ISSN 0012-1606. PMID 10837124.
  3. ^ Poss, K. D. (2002-12-13). "Heart Regeneration in Zebrafish". Science. 298 (5601): 2188–2190. doi:10.1126/science.1077857. ISSN 0036-8075. PMID 12481136.
  4. ^ Kikuchi, Kazu; Holdway, Jennifer E.; Werdich, Andreas A.; Anderson, Ryan M.; Fang, Yi; Egnaczyk, Gregory F.; Evans, Todd; MacRae, Calum A.; Stainier, Didier Y. R. (March 2010). "Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes". Nature. 464 (7288): 601–605. doi:10.1038/nature08804. ISSN 0028-0836. PMC 3040215.
  5. ^ Lepilina, Alexandra; Coon, Ashley N.; Kikuchi, Kazu; Holdway, Jennifer E.; Roberts, Richard W.; Burns, C. Geoffrey; Poss, Kenneth D. (November 2006). "A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity during Zebrafish Heart Regeneration". Cell. 127 (3): 607–619. doi:10.1016/j.cell.2006.08.052. ISSN 0092-8674.
  6. ^ Kikuchi, K.; Gupta, V.; Wang, J.; Holdway, J. E.; Wills, A. A.; Fang, Y.; Poss, K. D. (2011-06-08). "tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration". Development. 138 (14): 2895–2902. doi:10.1242/dev.067041. ISSN 0950-1991. PMC 3119303.
  7. ^ Wang, Jinhu; Cao, Jingli; Dickson, Amy L.; Poss, Kenneth D. (2015-05-04). "Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling". Nature. 522 (7555): 226–230. doi:10.1038/nature14325. ISSN 0028-0836. PMC 4494087.
  8. ^ Cao, Jingli; Wang, Jinhu; Jackman, Christopher P.; Cox, Amanda H.; Trembley, Michael A.; Balowski, Joseph J.; Cox, Ben D.; De Simone, Alessandro; Dickson, Amy L. (September 2017). "Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue". Developmental Cell. 42 (6): 600–615.e4. doi:10.1016/j.devcel.2017.08.024. ISSN 1534-5807.
  9. ^ Gupta, Vikas; Poss, Kenneth D. (April 2012). "Clonally dominant cardiomyocytes direct heart morphogenesis". Nature. 484 (7395): 479–484. doi:10.1038/nature11045. ISSN 0028-0836. PMC 3340018.
  10. ^ Mokalled, M. H.; Patra, C.; Dickson, A. L.; Endo, T.; Stainier, D. Y. R.; Poss, K. D. (2016-11-03). "Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish". Science. 354 (6312): 630–634. doi:10.1126/science.aaf2679. ISSN 0036-8075.
  11. ^ Kang, Junsu; Hu, Jianxin; Karra, Ravi; Dickson, Amy L.; Tornini, Valerie A.; Nachtrab, Gregory; Gemberling, Matthew; Goldman, Joseph A.; Black, Brian L. (April 2016). "Modulation of tissue repair by regeneration enhancer elements". Nature. 532 (7598): 201–206. doi:10.1038/nature17644. ISSN 0028-0836. PMC 4844022. PMID 27049946.
  12. ^ Goldman, Joseph Aaron; Kuzu, Guray; Lee, Nutishia; Karasik, Jaclyn; Gemberling, Matthew; Foglia, Matthew J.; Karra, Ravi; Dickson, Amy L.; Sun, Fei (February 2017). "Resolving Heart Regeneration by Replacement Histone Profiling". Developmental Cell. 40 (4): 392–404.e5. doi:10.1016/j.devcel.2017.01.013. ISSN 1534-5807. PMC 5367476. PMID 28245924.

External links[]

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