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KY 225 begins at an intersection with KY 92 southwest of Ingram, within Bell County. It travels to the northwest and immediately crosses over . It winds its way to the northwest, enters Knox County, and travels through . It curves to the north-northwest and enters Kayjay. There, it crosses over , curves to the east, and crosses over Tye Fork again. The highway begins paralleling the fork and curves to a northeast direction. Then, it curves to the north and passes Tinsley Cemetery before curving to the west-northwest and traveling through Trosper. It curves to the north and passes Burch Cemetery. KY 225 curves to the northeast and crosses Owens Branch. The highway curves to the north-northwest and crosses over and Cumberland River. It then enters Artemus, where it crosses over some CSX railroad tracks and intersects the western terminus of . It heads to the northwest, paralleling those railroad tracks. It curves to the north-northwest, crosses over , and enters Barbourville. It passes the and curves to the north-northeast. It passes Barbourville Cemetery. On the northeastern edge of the cemetery, it intersects the southern terminus of (Cumberland Avenue). At this same intersection, KY 225 heads to the southeast, curves to the northeast, and meets its northern terminus, an intersection with U.S. Route 25E (Cumberland Gap Parkway). Here, the roadway continues as the western end of .[1]