LEKTI-2
SPINK9 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | SPINK9, LEKTI2, serine peptidase inhibitor, Kazal type 9, serine peptidase inhibitor Kazal type 9 | ||||||||||||||||||||||||
External IDs | OMIM: 613511 HomoloGene: 88638 GeneCards: SPINK9 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 5: 148.32 – 148.34 Mb | n/a | |||||||||||||||||||||||
PubMed search | [2] | n/a | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the SPINK9 gene in humans. LEKTI-2 is an inhibitor of KLK5, a serine protease expressed in the epidermis and responsible for coordinating skin homeostasis and desquamation. SPINK9 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK6.[3]
See also[]
- Kazal-type serine protease inhibitor domain
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000204909 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Furio L, Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.
Categories:
- Genes on human chromosome 5
- Proteins
- Human chromosome 5 gene stubs