LEKTI-2

SPINK9
Identifiers
Aliases	SPINK9, LEKTI2, serine peptidase inhibitor, Kazal type 9, serine peptidase inhibitor Kazal type 9
External IDs	OMIM: 613511 HomoloGene: 88638 GeneCards: SPINK9
Gene location (Human)
Chr.	Chromosome 5 (human)
End	148,339,852 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; testicle; ; heart; ; caudate nucleus; ; nucleus accumbens; ; stomach; ; kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; GO:0001948 protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; acrosomal vesicle; extracellular space;
Biological process	negative regulation of peptidase activity; negative regulation of serine-type endopeptidase activity; cornification; regulation of acrosome reaction; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	643394
	n/a
	ENSG00000204909
	n/a
	Q5DT21
	n/a
	NM_001040433
	n/a
	NP_001035523
	n/a
	Wikidata
View/Edit Human

Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the SPINK9 gene in humans. LEKTI-2 is an inhibitor of KLK5, a serine protease expressed in the epidermis and responsible for coordinating skin homeostasis and desquamation. SPINK9 is a member of a gene family cluster located on chromosome 5q33.1, which includes SPINK5 and SPINK6.^[3]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204909 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Furio L, Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000204909 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[furio-3] Furio L, Hovnanian A. (November 2011). "When Activity Requires Breaking Up: LEKTI Proteolytic Activation Cascade for Specific Proteinase Inhibition". J Invest Dermatol. 131 (11): 2169–73. doi:10.1038/jid.2011.295. PMID 21997416.

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[2]

[3]

LEKTI-2

See also[]

References[]