Larry Sandler
Laurence Marvin Sandler (1929–1987) was a "leading Drosophila geneticist",[1] active during the mid-20th century. Sandler is best known for his work establishing and elucidating the phenomenon of meiotic drive. (Meiotic drive is when one copy of a gene is passed on to offspring more than the expected 50% of the time.)
Sandler earned a B.S. at Cornell University and did his doctoral work with at the University of Missouri, where he collaborated with .[2] Braver and Sandler discovered that meiotic was one driver of allelic variation in natural populations,[2] (Sandler & Braver 1954.[3]) a phenomenon coined "meiotic drive" in a follow-up paper by Sandler and Novitski.[2] (Sandler & Novitski 1957.[4]) Sandler also collaborated with Iris Sandler, his wife and fellow scientist, who also worked as a graduate student in Novitski's lab.[1]
In 1956, Sandler briefly joined the Biology Division at Oak Ridge National Laboratory, where Sandler and Dan Lindsley worked on sperm dysfunction.[1]
After joining the lab of Jim Crow at the University of Wisconsin, Sandler and began working on segregation distortion, publishing several papers together.[5]
Sandler moved to the University of Washington in 1962.[1] There he supervised numerous graduate students who joined the field, including Bruce Baker, Adelaide T. Carpenter, Ian Duncan, , Larry Goldstein, , Jeff Hall, Scott Hawley, Jim Mason, , , , , Bill Sullivan, , and Glenn Yasuda.[1]
Sandler was professionally active, involved in the founding of the Drosophila Research Conference, and transferring it to the Genetics Society of America.[1] He was also involved with other conferences, including the International Congress of Genetics, and as editor with numerous genetics journals, including Annual Review of Genetics and Genetics.[1]
Sandler was married to fellow scientist Iris Sandler, who ultimately became a historian of science.[1] The couple had two children, Jack and Dee Sandler.[1] He died in 1987.[1]
Significant papers[]
- Sandler & Braver 1954, "The meiotic behavior of grossly deleted X chromosomes in Drosophila melanogaster", Genetics v.43, pp. 547–563.
- Sandler & Novitski 1957, "Meiotic drive as an evolutionary force," American Naturalist v.91, pp. 105��110.
- D. L. Lindsley & L. Sandler, 1958, "The meiotic behavior of grossly deleted X chromosomes in Drosophila melanogaster", Genetics, 43:547-563.
- Larry Sandler and , 1960, "Meiotic drive in natural populations of Drosophila melanogaster", Genetics, 45:1671-1689 ("On the nature of the SD region").
Awards and recognition[]
- Honoree of the Larry Sandler Memorial Award, for the best Drosophila-related dissertation
- 1991 Memorial Symposium on Meiotic Drive, published in American Naturalist (1991)
- Annual Sandler Lecture hosted by the Genetics Department at the University of Washington
References[]
- Dan Lindsley, "Larry Sandler: Personal Recollections", Genetics 151: 1233–1237 (April 1999)
- "Larry Sandler: The Father of Meiotic Drive", The American Naturalist, Vol. 137, No. 3, pp. 283–286 (March 1991).
- Scott Hawley, "Meiosis as an "M"Thing: Twenty-Five Years of Meiotic Mutants in Drosophila", Genetics (1993)
- B. Ganetzky, "Yuichiro Hiraizumi and Forty Years of Segregation Distortion", Genetics 1999
- Notes
- ^ Jump up to: a b c d e f g h i j Dan Lindsley, "Larry Sandler: Personal Recollections" Genetics 151: 1233–1237 (April 1999)
- ^ Jump up to: a b c Dan Lindsley, "Larry Sandler: The Father of Meiotic Drive", The American Naturalist, Vol. 137, No. 3, pp.283-286 (March 1991).
- ^ Sandler & Braver 1954
- ^ Sandler & Novitski 1957
- ^ B. Ganetzky, "Yuichiro Hiraizumi and forty years of segregation distortion", Genetics (1999).
- 1929 births
- 1987 deaths
- American geneticists
- Cornell University alumni
- University of Missouri alumni
- University of Wisconsin–Madison faculty
- University of Washington faculty