Leucine rich repeat containing 15

LRRC15
Identifiers
Aliases	LRRC15, LIB, Leucine rich repeat containing 15
External IDs	MGI: 1921738 HomoloGene: 26080 GeneCards: LRRC15
Gene location (Human)
Chr.	Chromosome 3 (human)
End	194,369,743 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	30,102,074 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; tendon; ; tibia; ; hair follicle; ; Achilles tendon; ; zone of skin; ; gums;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibronectin binding; protein kinase inhibitor activity; laminin binding; collagen binding;
Cellular component	cytoplasm; integral component of membrane; extracellular exosome; membrane; extracellular space; GO:0005578 extracellular matrix; collagen-containing extracellular matrix;
Biological process	negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; positive regulation of cell migration; negative regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	131578
	74488
	ENSG00000172061
	ENSMUSG00000052316
	Q8TF66
	Q80X72
	NM_130830; NM_001135057
	NM_028973
	NP_001128529; NP_570843
	NP_083249
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine rich repeat containing 15 is a protein that in humans is encoded by the LRRC15 gene.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172061 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052316 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Leucine rich repeat containing 15".

Further reading[]

Reynolds PA, Smolen GA, Palmer RE, Sgroi D, Yajnik V, Gerald WL, Haber DA (September 2003). "Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein". Genes & Development. 17 (17): 2094–107. doi:10.1101/gad.1110703. PMC 196452. PMID 12923058.
Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ (February 2020). "Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy". Cancer Discovery. 10 (2): 232–253. doi:10.1158/2159-8290.CD-19-0644. PMID 31699795.
Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron JR, Bourgon R, Müller S, Turley SJ (May 2021). "Cross-tissue organization of the fibroblast lineage". Nature. 593 (7860): 575–579. doi:10.1038/s41586-021-03549-5. PMID 33981032.
Wang Y, Liu Y, Zhang M, Lv L, Zhang X, Zhang P, Zhou Y (March 2018). "LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation". Stem Cell Res Ther. 9 (1): 65. doi:10.1186/s13287-018-0809-1. PMC 5845373. PMID 29523191.
Cui J, Dean D, Wei R, Hornicek FJ, Ulmert D, Duan Z (September 2020). "Expression and Clinical Implications of Leucine-Rich Repeat Containing 15 (LRRC15) in Osteosarcoma". J Orthop Res. doi:10.1002/jor.24848. PMID 32902907.
O'Prey J, Wilkinson S, Ryan KM (June 2008). "Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy". Journal of Virology. 82 (12): 5933–9. doi:10.1128/JVI.02273-07. PMC 2395123. PMID 18385238.
Satoh K, Hata M, Yokota H (January 2002). "A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid". Biochemical and Biophysical Research Communications. 290 (2): 756–62. doi:10.1006/bbrc.2001.6272. PMID 11785964.
Satoh K, Hata M, Shimizu T, Yokota H, Akatsu H, Yamamoto T, Kosaka K, Yamada T (September 2005). "Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix". Biochemical and Biophysical Research Communications. 335 (2): 631–6. doi:10.1016/j.bbrc.2005.07.117. PMID 16098915.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172061 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052316 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leucine rich repeat containing 15".

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